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Aging Is Associated With Diminished Immunity

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5. Hypothesis
Aging is associated with diminished immunity. Macrophages, which play a pivotal role in the first line defense of pathogen invasion, have their endocytosis and lysosomal action delayed as people age. The capacity therefore of alveolar macrophages to kill mycobacterium tuberculosis is significantly compromised in aging populations. DM, tends to lower a persons’ immunity as evident in many studies [Nuria et al], hence, the hypothesis of this study was that there prevalence of DM is high amongst TB patients and there is increased risk of drug resistant TB with age among diabetic patients.

6. Study goals and objectives
The Primary goal of the study was to examine the distribution of DM among TB patients and explore the risk of Drug resistant TB in Diabetics who are also infected with TB in Florida, USA. The Florida department of health TB control program aims to eliminate TB in the state through TB care initiative, A Florida system of Tuberculosis care formed by partnership between the Florida Department pf Health (FDOH) and the public health system statewide to ensure availability of effective TB management program, an aim in line with the global plan to stop TB 2016-2020 adopted by WHO has a post 2015 strategy to eliminate TB as a global epidemic by 2035.
The research aimed to gain in-depth understanding of TB and drug resistant TB risk associated with DM in aging populations to initiate collaborative TB/DM control initiatives throughout the state of Florida

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