5. Hypothesis
Aging is associated with diminished immunity. Macrophages, which play a pivotal role in the first line defense of pathogen invasion, have their endocytosis and lysosomal action delayed as people age. The capacity therefore of alveolar macrophages to kill mycobacterium tuberculosis is significantly compromised in aging populations. DM, tends to lower a persons’ immunity as evident in many studies [Nuria et al], hence, the hypothesis of this study was that there prevalence of DM is high amongst TB patients and there is increased risk of drug resistant TB with age among diabetic patients.
6. Study goals and objectives
The Primary goal of the study was to examine the distribution of DM among TB patients and explore the risk of Drug resistant TB in Diabetics who are also infected with TB in Florida, USA. The Florida department of health TB control program aims to eliminate TB in the state through TB care initiative, A Florida system of Tuberculosis care formed by partnership between the Florida Department pf Health (FDOH) and the public health system statewide to ensure availability of effective TB management program, an aim in line with the global plan to stop TB 2016-2020 adopted by WHO has a post 2015 strategy to eliminate TB as a global epidemic by 2035.
The research aimed to gain in-depth understanding of TB and drug resistant TB risk associated with DM in aging populations to initiate collaborative TB/DM control initiatives throughout the state of Florida
The CDC website provides ample educational information regarding tuberculosis. It gives a detail description of what Tuberculosis is, the testing used and how it works. The website also addresses the risk factors of tuberculosis and warns that traveling to countries such as Africa, Asia and Central America puts them in a higher risk of contracting TB. In addition, it provides people with preventive measures to avoid being infected. They advise against close proximity with infected, and to be cautious around people working in health care facilities, prisons, shelter or an over populate area and advise to refrain from consuming unpasteurized milk products. In addition, the Website provides Data and Statistics, which can help support previous
TB is still proven to be a top killer around the world, and with more cases of drug resistant TB being reported daily, the cost of treating and preventing this disease will continue to be on the rise.
Once believed to be easily treated and prevented, Tuberculosis (TB) has recently been making a steady comeback. Previous to modern medicine, TB claimed millions of victims, spreading from person to person like wildfire. Around the 17th-18th centuries, the “White Plague” took the lives of 1 in 5 adults (20%) in Europe and North America (Iseman, 1994). However, as technological advances progressed, this seemingly ferocious viral disease became a primal, insignificant thing of the past. But, in the nature of all bacteria, TB has, in the recent years, mutated to become progressively drug resistant. Why is Tuberculosis coming back with a vengeance? Well, the answer’s quite simple. TB has done an amazing job of standing in the corner and
This study involved reviewed a program to determine the effectiveness of a program to control drug sensitive TB by improving the treatment adherence of patients. The study compared the results of a patient program involving education and counseling of the patient and family members followed by Text messages and phone calls to remind them to take medications and monitor treatment and side effects. This is compared to the WHO recommended treatment of requiring the patient to make daily visits to TB outpatient centers for drug administration.
Tuberculosis is a disease of an infectious nature caused by a bacterium known as mycobacterium tuberculosis. The disease spreads through the air. People with the disease can spread it to susceptible people through coughing, sneezing, talking or spitting. It mainly affects the lungs and other parts such as the lymph nodes and kidneys can also be affected. The symptoms for TB are fatigue, coughing, night sweats, weight loss and fever. One third of the population of the world is affected with mycobacterium tuberculosis. The rate of infection is estimated to be one person per second. About 14 million people in the world are infected with active tuberculosis. Drug resistant TB has been recorded to be a serious public health hazard in many countries. Resistant strains have developed making it difficult to treat the disease. TB has caused millions of death mainly in people living with HIV/AIDS ADDIN EN.CITE Ginsberg19981447(Ginsberg, 1998)1447144717Ginsberg, Ann M.The Tuberculosis Epidemic: Scientific Challenges and OpportunitiesPublic Health Reports (1974-)Public Health Reports (1974-)128-13611321998Association of Schools of Public Health00333549http://www.jstor.org/stable/4598234( HYPERLINK l "_ENREF_3" o "Ginsberg, 1998 #1447" Ginsberg, 1998). The World Health Organization came up with the DOTS (Directly Observed, Therapy, Short course) strategy. The approach involves diagnosing cases and treating patients with drugs for about 6-8
TB is an unevenly spread disease due to structural violence and cultural arrangements present in today’s society. These unnatural causes create a social and medical barrier that makes TB more
Tuberculosis (TB), which is brought on by contamination with an individual from the Mycobacterium tuberculosis complex, is a noteworthy reason for incapacity and passing in numerous parts of the world. The frequency (recently reported cases) of tuberculosis in Louisiana is near the normal occurrence in the United States. . In 2013, Louisiana: Ranked eleventh among the 50 states in TB rates (3 for each 100,000 people) and 22.3% of TB cases were foreign-born people (CDC, 2015). As in the U.S., frequency has diminished
Tuberculosis, the white plague as used to be called once upon a time is still one of the deadliest bacterial killers affecting almost all parts, all corners of the globe. Though successful anti-tubercular antibiotic regimens and effective vaccine are available for decades and being used in the battle against Koch’s bacillus, Mycobacterium tuberculosis, the causative agent of this chronic multi organ granulomatous disease, our strand in the battle continuously seems to be in the losing side. Moreover the increasing prevalence of HIV-AIDS and diabetes mellitus is being proved to be providing predisposition to tuberculosis. As witnessed by the WHO, which has estimated that, in the year 2012, 8.6 million people have developed tuberculosis and 1.3 million have died of the disease including 320000 deaths of HIV-TB co-infected people (Global tuberculosis report 2013. World Health Organization; 2013). Long term antibiotic therapy and that too associated with several side effects and discomforts have diminished patient compliance with the anti-tubercular chemotherapy. This fact in turn has raised the new deadlier MDR-TB and XDR-TB strains. The whole scenario is a matter of panic and questioning the effectiveness of anti-tubercular antibiotics, immunologic efficacy of century old BCG vaccine and all other medical advents.
Among many misconceptions, tuberculosis is not a disease of the past. Tuberculosis remains a public health issue. It is estimated that one-third of the total world population is infected by tuberculosis (TB). The American lung association (2013) states, in 2011 alone there were nearly 9,000,000 new diagnosed cases of tuberculosis around the world and an estimated 1.4 million deaths because of this disease. In the United States, TB is not as common (but still a problem). In 2011, only 10,500 people reported having TB (Trends in Tuberculosis Morbidity and
With the close proximity infection range TB is known for completes the remainder of the epidemiologic triangle. Overcrowded environments are the coal to the fire of this transmittable disease with outbreaks capable of occurring, infection hundreds. Common symptoms of this active form of tuberculosis include: weight loss, coughing, fatigue, fever, night sweats, chills, and loss of appetite (MayoClinic, 2014). The Mayo Clinic also states that it is believed that 2 billion (one third) of the world population is living with Latent TB (2014). This emphasizes the need for public health and community involvement in order to completely abolish this disease from our planet.
TB is caused by a bacterial infection known as mycobacterium tuberculosis. If a patient is sick with TB is considered a disease. The infection is prevalent in the HIV population because approximately 13 million Americans are effected by the TB bacteria. It typically involves the lungs but can also affect the brain and other organ systems. The TB germ is airborne and can live in the air for several hours. Once an affected person coughs or sneezes another person breathes in the germ and becomes infected. A patient with TB and HIV/AIDS will have to take an antibiotics long term to battle the infection. They will have to go through two phases of medication. The initial phase consists of utilizing drugs such as isoniazid, pyrazinamide, rifamycin, and ethambutol for the first couple of months. Then the patient will enter into the continuation phase, during this phase the patient will take the isoniazid and rifamycin for approximately four months. HIV patient’s that are taking antiretroviral for the HIV will have to take the antibiotics longer. A person taking treatment for TB has to be careful because the antibiotic can cause liver damage. According to the CDC, roughly 6% of all TB cases are from patients with HIV or AIDS. In 1992 the United States had a dramatic increase in TB cases but has decreased ever since. Recently a group of researchers at John Hopkins
This paper will discuss the relationship between the aging process and key diseases associated with aging. Examples of aging-associated diseases include cancer, diabetes, cardiovascular disease, and neurodegenerative diseases (López-Otín, Blasco, Partridge, Serrano, & Kroemer, 2013, p. 1194). Of these, we will discuss in-depth recent studies that have linked aging with Alzheimer’s disease, cardiovascular disease, and diabetes. These diseases affect a significant proportion of the population over the age of 65 and place a considerable burden on the American health care system. Therefore, a better understanding of how they are related to aging and each other can result in the adoption of innovative treatments and declined risk for older adults.
Chronic disease and conditions are usually defined as those diseases which last for more than six months and which have a severe effect on the life of the individuals (Chronic Conditions and Injury, para.1). While chronic diseases can affect people of all ages and demographics, these types of diseases are very often found in the elderly. Chronic disease are also characterized by "…multiple risk factors, long latency periods, a prolonged course of illness and functional impairment or disability" (Key indicators of progress for chronic disease and associated determinants, 2011, p. 1). Chronic disease is also found to be more prevalent in the ageing demographic of most countries.
The risk factors for contracting the disease vary according to age, health conditions, or location. The elderly people and infants are likely to get TB mainly because their immune systems are weak. As an individual grows old, the immune system weakens and this can increase chances of being
India, the second most populous country with over 1.31 billion people, has the highest burden of tuberculosis (TB) in the world, accounting for 20% of the global incidence of TB, and an even higher share of global incidence of multi–drug resistant (MDR) TB. With an estimated 2 million new cases of TB and 5, 00,000 TB-related deaths in India annually, those who got diagnosed with different forms of DR-TB were 35,385 cases but only 20,753 people started on multidrug-resistant TB (MDR-TB) treatment in 2013. The National Tuberculosis Program was launched in 1962, but suffered heavily continuing TB led mortality. Acknowledging this reality, a Revised National Tuberculosis Control Programme (RNTCP) was launched by the Government of India in 1997, however even today it does not comply with World Health Organization (WHO) recommendations.