Acute lymphoblastic leukemia(ALL), also known as lymphoblastic leukemia/lymphoma in the WHO classification, is a malignant expansion of immature lymphoid cells that results from multi-step genetic changes in a single lymphoid progenitor cell. Its incidence peaks between the ages of 2 and 4 years(1(.
Acute lymphoblastic leukemia (ALL) is the most common malignancy in children (2). ALL causes 77% of children leukemia, and acute myeloblastic leukemia (AML) counts for 11% (3). ALL is categorized based on cytogenetic and molecular criteria into a few subgroups for diagnosis, prognosis and treatment (4-6).
There is not any comprehensive information available in Iran about the prevalence of leukemia; however research indicates a high prevalence (7). Research showed that the prevalence of leukemia is 16.2% in Iran, which is a higher prevalence compared with skin, lung and breast cancers (8).
Acquired genetic changes that are likely to contribute to development of ALL include the dysregulation
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Two different forms are identified for ROR1 (13). One form lack all the out of cellular domains, which is called shortened or truncated- ROR1 (t- ROR1) (13). The second form lake the intra-cellular, and transmembrane domains. However most of studies have been performed on the long form (13). Some studies indicated that the intra-cellular domain lacks biologic activity, while others showed its vital role in transforming signal (11).
Many functions have been described for ROR; they are involved in cell polarity and tumor like behavior like migration and invasion (14, 15). The increased expression of ROR1 had been reported in acute and chronic lymphoblastic leukemia (16-18) and mantle cell lymphoma (19). Though the high expression of ROR2 is reported in osteosarcoma (15) and renal cell carcinoma (20). ROR1 also had been known as a diagnostic marker in chronic lymphoblastic leukemia (CLL)
The primary pathophysiological etiology for signs, symptoms and laboratory findings in 4 year-old John’s case study are secondary splenomegaly as a result of primary Acute Lymphoblastic Leukemia (ALL). Because of its proximity to
The American Revolution is considered a story of great success and perseverance of the colonists. It is full of grand battles and hard working soldiers, who fought against the Empire of Great Britain in order to gain the rights to life, liberty and the pursuit of happiness. This is the story that most Americans know and it is certainly what is taught in elementary and middle schools. Howard Zinn, author of A People's History of the United States, castigates this idea. In fact, he tells a very different story. Zinn believes that instead of a great fight for freedom, the American Revolution was full of inequality of rights, lack of American war effort and injustices in the Constitution.
There are two types of leukemia in children; acute and chronic. Acute is fast growing leukemia. Within acute leukemia are three categories: acute lymphocytic (lymphoblastic) leukemia (ALL), acute myelogenous leukemia (AML), and hybrid or mixed lineage leukemia. Acute lymphocytic (lymphoblastic) leukemia (ALL) is the most common type of childhood leukemia and develop from early forms of lymphocytes, also known as white blood cells. Specifically, three out of four childhood leukemias are ALL (About Childhood Leukemia). Acute myelogenous leukemia (AML) starts from the myeloid cells that create blood forming cells such as white blood cells (except for lymphocytes), red blood cells, and platelets (About Childhood Leukemia). Hybrid or mixed lineage leukemia are rare forms of childhood leukemia, but can be treated like ALL and AML. On the other end of the spectrum is chronic, or slow growing, leukemia. Chronic leukemia is difficult to treat and are more commonly found in adults than children. There are two types of chronic leukemia: chronic myelogenous leukemia (CML) and chronic lymphocytic leukemia (CLL). Chronic myelogenous leukemia (CML) is not commonly
Today I will be talking about three aspects of Leukemia; First what it is and one of the possible causes, Secondly what are the recognizable symptoms and what tests doctors use to identify leukemia in a young child. And what
According to the American Cancer Society (2013) stated, “Leukemia is a cancer that starts in early blood-forming cells” (American Cancer Society, 2013). “Most often, leukemia is a cancer of the white blood cells, but some leukemias start in other blood cell types” (American Cancer Society, 2013). “Any of the cells from the bone marrow can turn into a leukemia cell” (American Cancer Society, 2013). According to the American Cancer Society (2013) stated, “Once this change takes place, the leukemia cells don’t go through the normal process of maturing” (American Cancer Society, 2013). There are changes that leukemia cells can quickly reproduce themselves and not die when they are suppose too (American Cancer Society, 2013). “They survive and build up in the bone marrow, crowding out normal cells” (American Cancer Society, 2013). “In most cases, the leukemia cells spill into the bloodstream fairly quickly” (American Cancer Society, 2013). “Almost all childhood leukemia is acute leukemias” (American Cancer Society, 2013).
Leukemia is cancerous disease that starts in blood-forming tissue such as the bone marrow and causes large numbers of blood cells to be produced and enter the blood-stream (National Cancer Institute, 2008, para. 1). It is one of many complicated cancer diseases that affect all ages and have very negative outcomes if not treated properly, and on time. Within the disease are several different types that affect according to how quickly the disease develops and attacks the body. It could be classified as chronic leukemia, which has a slow progress of getting worse or acute leukemia which usually gets worse quickly. The types of leukemia also can be grouped based on the white blood cell that is affected (National Cancer Institute , 2008, p. 1).
Chronic Lymphocytic Leukemia (CLL) is slow-progressing or “chronic”, cancer of the blood and bone marrow. CLL is the second most common leukemia in adults and one of the four primary types of leukemia. Certain risk factors have been identified including age, race, sex, family history of blood and bone marrow cancers and chemical exposure. Most people diagnosed with CLL are white males over the age of 60. Occurrence increases with age and a marked increase after 60. Herbicides, insecticides and Agent Orange used in the Vietnam War have shown to increase the risk of developing CLL. There are approximately 15,000 new cases diagnosed each year.
Ashlei Frazier couldn't believe that her young daughter was the one out of many others to be diagnosed with this terrible disease. At 18 months Ashlei thought Madyn looked a little pale, she assumed it was just a virus. However, Madyn’s pediatrician suspected cancer, and immediately referred her to Valley Children's.
ERMs in general can regulate a number of processes important in tumor development and metastasis through the formation of membrane-cytoskeleton complexes, including cell adhesion, survival and cell migration (Bretscher et al., 2002; Clucas and Valderrama, 2014). As such it is not surprising that the other ERM proteins, radixin and moesin, have also been
When a parent takes their child to the doctor the last thing they want to hear is that their child has cancer. Unfortunately, it is not uncommon for a child to be diagnosed with Acute Lymphoblastic Leukemia, also known as ALL. Acute Lymphoblastic Leukemia is one of the most common forms of childhood cancer, and “makes up approximately 25% of cancer diagnoses among children under 15 years old” (3). Children under five years of age are at the most risk of developing ALL. Since it is an acute form of cancer once the onset has begun the disease quickly begins to worsen, therefore patients must seek treatment as soon as possible. “ALL is different than other diseases in that it is not just a single disease but also rather a group of related diseases with different subtypes”(1). This uniqueness causes the treatment of ALL to depend on the subtypes the patient has, therefore each
Acute Lymphocytic Leukemia is a scary disease. The term “acute” means the disease can quickly spread and progress quickly and can prove fatal in months if left untreated. “Lymphocytic” simply means that it develops from immature forms of lymphocytes. Also known as Acute Lymphoblastic Leukemia, or ALL for short, it is a type of cancer that starts from the early form of white blood cells called lymphocytes in the bone marrow. ALL is the most common form of cancer in children, though adults can get it as well. For children, treatment results in a good chance of a cure. Adults have a significantly smaller chance of a cure with ALL. ALL generally invades the blood very quickly and has the potential to spread to other body parts such as the spleen,
Death is terrifying. This is the argument made by John Keats in his poem “A Draught of Sunshine,” in which he details the inevitable string of emotions which every man must experience on his deathbed. Keats uses a combination of religious allusion, ironic imagery, and an anxious tone to convey this message. Without the speaker’s religious allusions, the reader would have a difficult time recognizing the speaker’s fate in the poem – death.
- Fact/evidence to support reason #1: The second highest kind of cancer in children is brain cancer.
There are two main and four specific types of leukemia. The two main types are acute leukemia, which is fast growing, and chronic leukemia, which is slow growing. The four specific types of leukemia are chronic lymphocytic (CLL), acute lymphocytic (ALL), chronic myelogenous (CML), and acute myelogenous (AML) that were discovered in 1913. About three quarters of children diagnosed with leukemia have acute lymphocytic which peaks as early as two to four years old. This cancer kills more children that are two or fifteen than anything else. To determine whether the cancer will be chronic or acute is to look at the cell lineage. The blood cell that becomes cancerous explains what type of leukemia it is. Depending on if the white cells, the red blood cells, or the platelets can determine exactly which leukemia it is. “Adults can get either type; children with leukemia most often have an acute type” (Leukemia: MedlinePlus). For a child to get a chronic leukemia is very rare. Now it is known that the cancer starts in the bone marrow, which is where blood cells are formed. Leukemia causes the body to create too many abnormal cells and these abnormal white cells cannot fight infection and also lessen the amount of red cells and platelets. Some of the risk factors of this cancer are large doses of ionizing radiation, being exposed to benzene for a long period of time, rare viruses, genetic disorders, and
The Movie “We’re The Millers” is a dark comedy movie about a small-time pot (marijuana) dealer called David Clark, who in the beginning of the movie gets robbed of his money and stash, which he owes most of to his “boss” who is a wealthy drug supplier known by the name Brad Gurdlinger, from a group of street thugs who were trying to rob a runaway girl whom his teenage neighbor (Kenny) was trying to help get her phone back. Therefore, David is forced to smuggle drugs for his boss across the border from Mexico back into Denver, because he has no other choice but to do so, thus, in order for him to do the job he assembled a fake family composed by him, his teenage neighbor, a local runaway, and his other neighbor (known as Rose, who is a broke stripper whom her boyfriend took all her money and ran outside the country). David shows the commitment, confidence, and leadership throughout the movie to do his job or else he would get killed by brad, but by continuing his job he faces a lot of setbacks and other problems along the way which he is able to solve by the end of the movie.