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Acute Lymphoblastic Leukemia

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Acute lymphoblastic leukemia(ALL), also known as lymphoblastic leukemia/lymphoma in the WHO classification, is a malignant expansion of immature lymphoid cells that results from multi-step genetic changes in a single lymphoid progenitor cell. Its incidence peaks between the ages of 2 and 4 years(1(.
Acute lymphoblastic leukemia (ALL) is the most common malignancy in children (2). ALL causes 77% of children leukemia, and acute myeloblastic leukemia (AML) counts for 11% (3). ALL is categorized based on cytogenetic and molecular criteria into a few subgroups for diagnosis, prognosis and treatment (4-6).
There is not any comprehensive information available in Iran about the prevalence of leukemia; however research indicates a high prevalence (7). Research showed that the prevalence of leukemia is 16.2% in Iran, which is a higher prevalence compared with skin, lung and breast cancers (8).
Acquired genetic changes that are likely to contribute to development of ALL include the dysregulation …show more content…

Two different forms are identified for ROR1 (13). One form lack all the out of cellular domains, which is called shortened or truncated- ROR1 (t- ROR1) (13). The second form lake the intra-cellular, and transmembrane domains. However most of studies have been performed on the long form (13). Some studies indicated that the intra-cellular domain lacks biologic activity, while others showed its vital role in transforming signal (11).
Many functions have been described for ROR; they are involved in cell polarity and tumor like behavior like migration and invasion (14, 15). The increased expression of ROR1 had been reported in acute and chronic lymphoblastic leukemia (16-18) and mantle cell lymphoma (19). Though the high expression of ROR2 is reported in osteosarcoma (15) and renal cell carcinoma (20). ROR1 also had been known as a diagnostic marker in chronic lymphoblastic leukemia (CLL)

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