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A Study On Diabetic Patients

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Diabetic patients have a major risk of cardiovascular disease leading cause of life threatening and death. The goal of this study is to select drugs that do not increase cardiovascular risk. The US FDA has recommended in its Guidance for Industry for drug developers in year 2008, that type 2 diabetes new drugs for clinical trials should fulfill gycemic benefit and cardiovascular safety, and rule out potentially harmful drug interactions. The European Medicines Agency recommended same. Cautious selection of the drug therapy, specifically cardiovascular safety with controlled diabetes. Patients with diabetes often showing atherosclerosis and are at high risk of morbidity and mortality from cardiovascular disease (CVD). Patients with diabetes have twice threat for stroke, heart related disease, and death from heart disease compared to non diabetic patients. Statics of 2010 showed that 1.9 million people aged 22 years or above in the US were identified with diabetes. Metformin is first choice of the treatment for type 2 diabetes mellitus due to its very effective glucose lowering formula, used from last many years, cheap, no effect on weight, causes least hypoglycemia, taken orally, and has the possible to decrease CV harm. Saxagliptin is basically a Dipeptidyl peptidase 4 (DPP-4) enzyme that reduced 0.6%-0.9% HgA1c by increasing body’s sugar utilization, prevent atherosclerosis and myocardial damage, improving lipid profile and endothelial dysfunction, and lower the blood

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