Life: The Science of Biology
11th Edition
ISBN: 9781319010164
Author: David E. Sadava, David M. Hillis, H. Craig Heller, Sally D. Hacker
Publisher: W. H. Freeman
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Chapter 47.2, Problem 1R
Summary Introduction
To review:
The mechanism, by which force generation in a muscle is controlled by nervous system, based on the relationships between skeletal muscles and motor neurons.
Introduction:
The acetylcholine is a neurotransmitter released by motor neurons to activate the muscles. At the neuromuscular junction, the acetylcholine is released from the presynaptic neuron membrane and bind to the receptors present on the postsynaptic muscle membrane.
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In light of the “all or none” law of muscle contraction, how can you explain twitch recruitment (also called the graded response) when stimulating the muscle versus stimulating the nerve? Explain the difference in stimulation voltage required to elicit a maximum response when stimulating the nerve versus the muscle directly?
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Motor neurons release what type of neurotransmitter onto the motor end plate of skeletal muscles? What effect does this neurotransmitter have on the postsynaptic membrane?
Chapter 47 Solutions
Life: The Science of Biology
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- Skeletal muscle is described as striated. What are the lighter, thinner stripes noted under the microscope? Group of answer choices troponin actin myosin dystrophin Rather than innervating individual muscle fibers, motor neurons often innervate two or more muscle fibers. The motor neuron and the muscle fibers it innervates are together called a: Group of answer choices motor unit myofibril muscle fascicle motor fascia Fast glycolytic muscle fibers allow for relatively quick ATP energy production by splitting glucose (but eventually leads to fatigue), a process described as: Group of answer choices fermentation aerobic pathway anaerobic pathway ATP reserve usearrow_forwardA motor unit associated with the stimulation of skeletal muscle is designated as a 1:8 motor unit. Which of the following statements is correct? The motor unit consists of one somatic neuron and 8 myofibers (muscle fibers) Each of the myofibers in the motor unit is innervated by more than one neuron It is part of the autonomic nervous system The neuron in the motor unit is an afferent neuronarrow_forwardPut these events that occur in skeletal muscle in the correct chronological sequence: 1. Activation of voltage-gated dihydropyridine (DHP) receptor in the T-tubule 2. Opening of mechanically-gated ryanodine receptors (RyR) on the sarcoplasmic reticulum 3. Na+ influx through ligand-gated ion channels on the motor end plate 4. Ca2+ binding to troponin 2, 1, 4, 3 4, 3, 2, 1 4, 3, 1, 2 3, 1, 4, 2 3, 1, 2, 4arrow_forward
- Which of the following step(s) about the excitation of skeletal muscle is/are incorrect? 1. Acetylcholine is released and binds to motor end plate receptors 2. An action potential is created and moves down T-tubules 3. Calcium is released from the sarcoplasmic reticulum 4. Calcium ions bind to tropomyosin to shift troponin off the binding sites for cross-bridging 5. Myosin forms cross-bridges and binds with actin to pull it towards middle of sarcomerearrow_forwardPut these events that occur in skeletal muscle in the correct chronological sequence: 1. Opening of mechanically-gated ryanodine receptors (RyR) on the sarcoplasmic reticulum 2. Ca²+ binding to troponin to initiate contraction 3. Activation of voltage-gated dihydropyridine (DHP) receptor in the T-tubule 4. Na+ influx through ligand-gated ion channels on the motor end plate 4, 3, 2, 1 2, 1, 4, 3 3, 1, 2, 4 4, 3, 1, 2 3, 1, 4, 2arrow_forwardDescribe the structures and functions of actin-based motor proteins, myosins.arrow_forward
- Explain how optimal skeletal muscle force (high muscle tension) can be achieved during a high intensity exercise. (Mention and explain how wave summation, motor recruitment summation, muscle length, and type of muscle fibers activated can affect muscle force).arrow_forwardThe single-fiber twitch experiments shown here were generated by stimulating the muscle cell membranes to threshold with an electrode and measuring the resulting action potential and force. How would the results differ if Ca21 were removed from the extracellular solution just before the electrical stimulus was applied?arrow_forwardFrom the following choices, choose the THREE, that would result in prevention of muscle contraction (in other words, which three descriptive changes below would result in flaccid paralysis of a muscle). exocytosis of acetylcholine is constant, even without action potential injection of botulinum toxin calcium cannot be pumped back into the terminal cisternae acetylcholine receptor remains open to sodium active sites on actin a permanently exposed dramatically increase the activity of acetylcholinesterase calcium cannot bind troponinarrow_forward
- Skeletal muscle cells undergo contractions based on a molecular mechanism involving: 1)the sliding of actin and myosin filaments past each other without any change in filament length 2) the shortening of actin filaments following direct interaction with myosin 3) dynamic instability of microtubules 4)nonearrow_forwardWe move a lot and do not even realize how intricate these movements may be from gross motor to fine motor manipulations. Briefly explain the steps involved in a single muscle contraction beginning at the neuromuscular junction through one complete contraction and relaxation for the sliding filament theory. Don’t forget to include all the major proteins (actin, myosin, troponin and tropomyosin) involved as well as calcium and ATP.arrow_forwardA) Assuming that each individual muscle fiber generates the same amount of tension, which of the following skeletal muscles will produce the greatest amount of overall tension when fully stimulated? Muscle Total Number of Muscle Fibers in Muscle A 150 B 1000 C 600 Group of answer choices Muscle A Muscle B Muscle C B)The following list of events take place during a muscle contraction. Place the events in chronological order as they relate to a muscle contraction. Calcium is released from the sarcoplasmic reticulum. Myosin heads bind to actin. An action potential arrives at the axon terminal of a motor neuron. Calcium binds to troponin, displacing tropomyosin and exposing myosin head binding sites on actin. Myosin heads undergo power stroke and actin slides over myosin towards M line of sarcomere. Acetylcholine is released at the neuromuscular junction.arrow_forward
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