What is the significance of the blue regions of the following molecule? Me Me pe steroid skeleton Me O None of the answers O They are prone to metabolism, thus limiting the lifetime of the drug O They introduce a dipole moment to the molecule allowing the correct alignment of binding groups when the molecule binds to the binding site O They represent the skeleton of acetylcholine O They are polar groups that increase water solubility
Q: Problem: From the following information determine the amino acid sequence of a peptide. N-terminal…
A: When a polypeptide undergoes edman degradation it gives PTH derivative of an amino acid residue. The…
Q: . The structure of certain porin proteins is organized into an interesting beta-barrel, in which…
A: IntroductionStructureAquaporin have structure consisting of 6 member helical structure forming…
Q: During fasting or starvation, the body converts to the production of ketone bodies. Diagram…
A: The objective of the question is to understand the biochemical pathways involved in the production…
Q: II. Analysis. Given below is a schematic diagram for a simple analysis of a novel tetrasaccharide…
A: Benedicts test : This is the biochemical test that is used to identify the presence of reducing…
Q: What is the approximate pl of the peptide "HYTCD"? 04.5 7.00
A: Peptide have difference in the charge based on the ionizable groups present. The peptide have 4…
Q: Use the diagram below to answer the following question. Identify the protein that was run on Mass…
A: We are given the spectrogram of an ESI-MS (Electrospray ionization Mass Spectroscopy). In this…
Q: protein is purified and at a concentration of 600 μg in 1.75 ml of buffer. You do an assay with your…
A: Protein purification is a fundamental process in biochemistry that involves isolating a specific…
Q: The data in the table are used to create a calibration curve for the determination of RNA from ts…
A: There are four classes of biological macromolecules: proteins , nucleic acids, lipids and…
Q: Sketch the titration curve for the amino acid alanine with pka1 = 2.34 and pka2 = 9.69.
A: Titration can be referred to as the effect of pH on amino acid structure. Titration curve of amino…
Q: Which of the following metal complexes are responsible for the reduction of molecular oxygen? Group…
A: The question is asking us to identify which metal complex is responsible for the reduction of…
Q: Exercise 6.3 Explain what happening (phenotype) to the following E. coli mutants when they are grown…
A: The objective of this question is to understand the phenotypic behavior of two different E. coli…
Q: how is sfGFP different than the wildtype GFP found in jellyfish
A: The question is asking about the differences between sfGFP (superfolder Green Fluorescent Protein)…
Q: Consider a gene being transcribed at a constant rate k1 and being degraded with first order…
A: The genetic information from protein synthesis is stored in DNA. This information is copied onto an…
Q: why does A2-B3 structure is active (contain the antibiotic) and the (A2-…
A: Aldehydes and ketones react with hydrazine to form hydrazones which is a part of Wolff-Kishner…
Q: Carbohydrates differ in solubility based on the size of the molecule. Which of the following…
A: Carbohydrates are the biomolecules which are classified into monosacharides, oligosaccharides and…
Q: 2B. S. aureus hemolysin B attacks the RBC cell membrane by hydrolyzing the sphingomyelin headgroup:…
A: Sphingomyelin is a phospholipid which has phosphocholine as head group and sphingosine as platform…
Q: GQ 7
A: The objective of the question is to determine the probability of a couple having a child with green…
Q: Reciprocal strand exchange is associated with ... O DNA photolyase site-specific recombination O…
A: Reciprocal strand exchange of DNA is defined as the exchange of equal segments of DNA between two…
Q: 1² L-^ 0.1 + ||| -4-2 |||| 24 [S]-1, (mM-1) 1, The value of Km for the enzyme depicted by curve A is…
A: Km is the Michelle's menton constant which is equal to the substrate concentration at half of the…
Q: Transport of maltose from the extracellular space to the cytoplasm of Gram-negative bacteria…
A: Gram-negative bacteria are a group of bacteria that do not retain the crystal violet stain used in…
Q: Watch the following videos and answer the questions below. 1. Basic chemistry for Physiology…
A: In Biochemistry there are various terms used to describe things which have a very important meaning…
Q: 3) Histone deacetylases (HDACs) are zinc-dependent enzymes that catalyse the conversion of…
A: Histone deacetylase (HDAC) converts acetyllysine to lysine by removing acetyl group from lysine. The…
Q: Antibodies are one of the key elements in the human immune system. a. What is the general structure…
A: A big Y-shaped protein called an antibody (Ab), sometimes referred to as an immunoglobulin (Ig), is…
Q: An engineered ligand binds its target with 5 nM affinity at high pH. However, protonation of a…
A: An engineered ligand (L) binds to a target protein (T) to form a ligand:target complex (LT). The…
Q: The data in the table are used to create a calibration curve for the determination of RNA from ts…
A: The 'least square method' is an alternate name for the linear regression model of statistical…
Q: True or False: The presence of Howell-Jolly bodies on a blood smear is indicative of asplenia or…
A: Howell-Jolly bodies are clusters of DNA which are nothing but basophilic nuclear remenents present…
Q: Under what conditions do the wasteful side reaction of O2 with rubisco become significant? a.) at…
A: Rubisco, or Ribulose-1,5-bisphosphate carboxylase/oxygenase, is a crucial enzyme in the process of…
Q: Leu-Glu-Glu-Val-Phe-Ser-Gln-Leu-Cys-Thr-His-Val-Glu-Thr-Leu-Lys a) Circle all of the hydrophilic…
A: Answers to a) and b)Hydrophilic amino acid residues are circled and hydrophobic amino acid residues…
Q: Question 6 Listen In fruit flies, yellow body is a sex linked recessive allele. The dominant allele…
A: The question is asking us to determine the percentage of male offspring that will have a yellow body…
Q: Using the catalytic mechanism of serine proteases, draw and label a reaction coordinate…
A: In order to draw the reaction coordinate diagram of the chymotrypsin catalyzed hydrolysis of a…
Q: IX. Draw the structure of the polynucleotide below which corresponds to a codon in the mRNA that…
A: A nucleotide is compound made up of three components: a pentose sugar (ribose for RNA and…
Q: Assessment 2: scenario based assessment Instructions This is a ‘scenario problem’. Read the…
A: The objective of the first question is to determine the optimal speed of travel for the treasure…
Q: Substrate DADEPYLIPQQG DADAPYLIPQQG DAAEPYLIPQQG AAAAPYLIPQQG . kcat 8-1 44.6 1.8 39.8 ± 0.32 35.3 ±…
A: Michaelis-Menten model of enzyme kinetics is a very useful model which describe the relationship…
Q: 3. Amino acid residues and peptide bonds (a) Draw the chemical structure of F, S and H joined by…
A: Amino acids are biomolecules that have a hydrogen atom, an amino group and a carboxyl group linked…
Q: 8.) Monosaccharides - 2 A. Circle the stereocenters in this monosaccharide structure. B. Identify…
A: The given question relates to the stereochemistry of carbohydrates.Stereocenter: The carbon center…
Q: What are the biological actions of enzymes ? What reactions do they catalyze? please include…
A: 1. Overview of Enzymes: Since they catalyze chemical reactions in living things without being…
Q: Draw the chain of atoms that are part of the covalent backbone that runs the length of the DNA…
A: DNA is composed of 2 polynucleotide strands. These DNA strands have a covalent backbone which is…
Q: 9. 3 μL of a 45 mM stock solution of a substrate is added to 8 mL of water. Calculate the following…
A: The objective of this question is to calculate various parameters related to a solution of a…
Q: Please discuss the buffering capacity of an amino acid. In your answer include what is a buffer? Why…
A: Amino acids are organic compounds that serve as the building blocks of proteins. They have three…
Q: (c) ADP binds to platelets to initiate the activation process. Two binding receptors were identified…
A: Dissociation constant Kd is used to describe the affinity of a receptor to its ligand . It is a…
Q: Mitchell presented theoretical calculations to show how a reversible ATPase system located in a…
A: In an anisotropic reversible ATPase system ATP hydrolysis is not consistent or equal in all…
Q: Riboswitches... permit transcription elongation only when bound to a small-molecule ligand. are…
A: Riboswitches are the mRNA segments that act as regulatory elements. They are involved in the control…
Q: What to submit: Draw in the hydrogen bonds for parallel and antiparallel sheets and replace the…
A: The proteins are a major class of biological macromolecules that are composed of amino acids…
Q: II. Lipids from an organic sample are extracted separately by column chromatography using the ff…
A: The objective of the question is to identify the lipids present in each eluate based on the test…
Q: r^2=6Dt , where D is the diffusion coefficient of thediffusing object and t is the time that the…
A: The objective of the question is to find out the time it takes for a protein to diffuse across a…
Q: 2. Given the data in the table, calculate the pl for the amino acid tyrosine. Amino Acid Glycine…
A: The proteins are biological macromolecules that are composed f amino acids connected via peptide…
Q: A mixture of proteins contains Trypsinogen (24 kDa), fumarase (49 kDa), Transferrin (80 kDa) and…
A: Chromatography is a form of an analytical method that breaks down a chemical mixture into its…
Q: Check the box under each molecule for which the statement in the first column is true. statement It…
A: The majority of biological processes require ribonucleic acid (RNA), a polymeric molecule that…
Q: Decide whether each of the following statements is true about oxaloacetate decarboxylase. If you…
A: Oxalo acetate decarboxylase( OAA decarboxylase ) is an enzyme that catalyses the conversion of…
Q: If you were reading a published journal article, where would you be most likely to find the…
A: A research article is an rticle that has been published in a journal.In such an article the authors…
Step by step
Solved in 3 steps
- The following structure is more active than morphine as an analgesic. H3C CH3 H. H3C' O Il.. What is the principal reason for this? The extra acetyl group binds to cell surface receptors improving active internalization. The acetyl groups mask a polar group allowing the structure to cross the blood brain barrier more efficiently. The extra acetyl group masks an alcohol group which would otherwise undergo a phase Il metabolic conjugation reaction leading to rapid excretion of the drug. The acetyl groups increase the stability of the drug in the cellular environment. O Il..Which of the following statements is true O Sphingomyelin posses phosphoryl serine in addition to two long hydrocarbon chains, one contributed by a fatty acid and the other by sphingosine OLipid compositions of membrane mono-layers are symmetrical O Unsaturated fatty acids have double bond(s) in the cis configuration In ABO blood typing, lack of glycosyltransferase and galactosyltransferase produces AB blood groupAcetylcholine is inactivated by the enzyme acetylcholinesterase. Which amino acid residue's side chain plays an important role as an acid-base catalyst in the enzyme's mechanism of action? O Glycine O Lysine Histidine Alanine O Asparagine
- Treatment of a polypeptide with 2-mercaptoethanol yields two polypeptides 1. Ile—Val—Cys—Arg—Thr—Gly—Cys—Lys—Asn—Phe—Leu2. Trp—Lys—Cys—Phe—Arg—His—Thr—Lys—Cys—SerTreatment of the intact polypeptide with trypsin yields fragments with the following aminoacid compositions(Arg, Cys2, Ile, Ser, Val)(Arg, Cys2, Gly, Lys, Thr, Phe)(Asn, Leu, Phe)(His, Lys, Thr)(Lys, Trp)Edmands chemistry reveal the following PTH derivatives in equal quantity after cycle 1• PTH--Ile and PTH--Trp a) Rewrite the intact polypeptide, by indicating the positions of the disulfide bonds(Indicate your reasoning) b) How many products do you expect after chymotrypsin cleavage of the intactpolypeptide? c) You are performing an isoelectric focusing experiment (IEF) on a gel with a pH range of 2to 14. Indicate on the diagram below at what point along the gel will peptide 1 abovefocus, in the presence (X) and absence (Y) of DTT. (also show your calculations)Which of these heterocyclic drugs is likely to be the least soluble in water? Use the Fsp³ parameter to decide. OH Tramadol Chemical Formula: C16H25NO2 YOUR OW Pantoprazole Torasemide Chemical Formula: C16H15F2N3O4S Chemical Formula: C16H20N4O3S Temazepam -OH Chemical Formula: C16H13CIN₂O2 Tioconazole Chemical Formula: C16H13C3N₂OS A. Tramadol B. Pantoprazole C. Torasemide D. Temazepam E. ToconazoleGive the product of this reaction sequence: NH3* Bg-CH3 Bg SH (cobalamin) Adenosyl-S H₂C-NH OH A Adenosyl-O intermediate D HN-CH3 Adenosyl-NH HS SH B ATP O-CH3 PPP₁ H3C-S+ Adenosyl H₂N E Adenosyl-O product OH с NH₂ S-CH3
- Which of the following statement is FALSE ? pKa values of active site residues can be shifted from typical pKa values Enzymes increase Keq Near attack complexes have reacting molecules close enough to form Va der Waals contacts The transition state contains at least one partial bond. QUESTION 12 The angle o in a peptide best describes: O the angle between the two peptide bonds O the angle between the alpha carbon (Ca) and the amide O the angle between the alpha carbon (Ca) and the carbonyl O the angle between the alpha carbon (Ca) and its side chain QUESTION 13 Investigating how protein subunits come together studies: super- secondary structure Click Save and Submit to save and submit. Click Save All Ansuers to save all anscers 7977 Mostly cloodyRegarding the mechanism of action of chymotrypsin, the formation of a strong hydrogen bond with the hydroxyl group (serine amino acid) increase its: Basicity Nucleophilicity All the answers are correct Electron densityAllosteric inhibitors of hemoglobin will decrease enzyme activity (oxygen binding) through which of the following mechanisms? Binding the enzyme in "T" conformation and displacing an activator Binding the enzyme and enhancing the Vmax Binding the enzyme, and keeping it in the "R" conformation Binding the enzyme, and keeping it in the "T" conformation
- please show DETAILED mechanism and I will upvote: biotin carboxylase Ö— NH N-carboxyblotin O-C-OH + ATP bicarbonateOne of the following glycosaminoglycans is anti-coagulant O Heparan sulphate O Hyaluronic acid O Heparin sulphate O Keratan sulphate O Chondroitin sulfate searchWhich of the following statements is not true about the catalytic triad in chymotrypsin? Group of answer choices the side chain of the serine 195 is hydrogen bonded to the imidazole ring of histidine the -NH group of the imidazole ring of histidine is hydrogen bonded to the carboxylate group of aspartate 102 the histidine residue serves to position the aspartate 102 side chain and to polarize its carboxylate group so that it is poised for deprotonation histidine acts as a general base catalyst none of these