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Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a disorder that affects the normal function
of red blood cells and can eventually lead to anemia. The trait is controlled by a recessive allele found on
the X chromosome. An affected son was born to a man and woman who were unaffected. The woman’s
mother was affected while the father was normal.
a. Indicate the gene notation.
b. Give the genotypes of the affected boy’s parents
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- Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a disorder that affects the normal function of red blood cells and can eventually lead to anemia. The trait is controlled by a recessive allele found on the X chromosome. An affected son was born to a man and woman who were unaffected. The woman’s mother was affected while the father was normal. a. Indicate the gene notation. b. Give the genotypes of the affected boy’s parents. c. Derive the genotypic and phenotypic ratios for the offspring. Show and label your solutions properly. d. What is the probability that they will have a phenotypically normal daughter as their first child? e. If they have four children, what is the probability that three out of their four children will be normal and one will be affected?Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a disorder that affects the normal function of red blood cells and can eventually lead to anemia. The trait is controlled by a recessive allele found on 4. the X chromosome. An affected son was born to a man and woman who were unaffected. The woman's mother was affected while the father was normal. a. Indicate the gene notation. b. Give the genotypes of the affected boy's parents. Derive the genotypic and phenotypic ratios for the offspring. Show and label your solutions properly. What is the probability that they will have a phenotypically normal daughter as their first child? C. d.Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a disorder that affects the normal function of red blood cells and can eventually lead to anemia. The trait is controlled by a recessive allele found on the X chromosome. An affected son was born to a man and woman who were unaffected. The woman's mother was affected while the father was normal. Indicate the gene notation. Give the genotypes of the affected boy's parents. Derive the genotypic and phenotypic ratios for the offspring. Show and label your solutions properly. What is the probability that they will have a phenotypically normal daughter as their first child? a. b. С. d.
- Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a disorder that affects the normal function of red blood cells and can eventually lead to anemia. The trait is controlled by a recessive allele found on the X chromosome. An affected son was born to a man and woman who were unaffected. The woman's mother was affected while the father was normal. Indicate the gene notation. Give the genotypes of the affected boy's parents. Derive the genotypic and phenotypic ratios for the offspring. Show and label your solutions properly. What is the probability that they will have a phenotypically normal daughter as their first child? а. b. С. d.Duchenne muscular dystrophy is sex linked and usuallyaffects only males. Victims of the disease become progressively weaker, starting early in life.a. What is the probability that a woman whose brotherhas Duchenne’s disease will have an affected child?b. If your mother’s brother (your uncle) had Duchenne’sdisease, what is the probability that you have receivedthe allele?c. If your father’s brother had the disease, what is theprobability that you have received the allele?In individuals affected by cystic fibrosis, salt crystals may appear afterperspiration dries up. In addition, the disease causes respiratory disorderswhich can be both debilitating and lethal. It occurs in individuals homozygousfor the recessive gene. Two normal parents had a daughter with thesymptoms of this disease, and a normal son who marries a normal womanwith an afflicted A test (salt concentration in perspiration of heterozygotes ishigher than normal) disclosed that both are indeed carriers of the gene. If thefirst child born to the mating in (b) was defective, what is the probability thatthe 2nd child would also be defective?Express answer in fraction form
- Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a disorder that affects the normal functionof red blood cells and can eventually lead to anemia. The trait is controlled by a recessive allele found onthe X chromosome. An affected son was born to a man and woman who were unaffected. The woman’smother was affected while the father was normal. c. Derive the genotypic and phenotypic ratios for the offspring. Show and label your solutions properly.d. What is the probability that they will have a phenotypically normal daughter as their first child?Alpha thalassemia is a hereditary blood condition that results in varying levels of anemia. It is tied to the HB alpha 1 gene and the HB alpha 2 gene on human chromosome 16. The diagram shows the proteins for the hemoglobin genes and the pedigree shows genotypes, designated by the letter X, on the chromosomes for a family affected by the condition. Which represents the predicted level of anemia in a child born to the mother and father in the image with a mutation that results in a genotype of xxxx? Why? A - mild anemia because the loss of 4 genes would equal the loss of the 4 proteins needed for normal alpha hemoglobin B - severe anemia because the loss of 4 genes would equal the loss of the 4 proteins needed for normal alpha hemoglobin C - mild anemia because the addition of 4 genes would produce too many of the proteins needed for normal alpha hemoglobin D - severe anemia because the addition of 4 genes would produce too many of the proteins needed for normal alpha hemoglobinSickle cell anemia is an inherited red blood cell disorder in which there are not enough healthy red blood cells to carry oxygen throughout the body. The allele that causes sickle-cell anemia is autosomal recessive (s), and the dominant allele can be represented by S. How many offspring will be affected by the disorder if the mother is a carrier, and the father appears to be normal? (Include the gender) a. b. How many will become carriers? (include the gender) A- 三三三 四 四 II !!
- Hemophilia A is caused by a recessive X-linked allele that encodes a defective form of a clotting protein. If a affected father and a mother who is known to not be a carrier have children, what percentage of female offspring will have hemophilia?The genetic disease hemophilia A is a sex-linked trait. Jane has an uncle on her father's side of the family who has hemophilia A, her father does not have hemophilia A. On Jane's mother's side of the family there has never been a case of hemophilia A. Should Jane be concerned about passing the gene for hemophilia A to her own children? Explain your answer.Cystic fibrosis (CF) is an autosomal recessive condition triggered by the overproduction of stickymucus that clogs the lungs and pancreas. It is a life-threatening disease, but medical advances helpedthe afflicted to live through adulthood.The mother of Claudia died from cystic fibrosis, but her father was normal and never had anyrelative with CF. Her fiancé, Marcus, turned out to be a carrier of the CF allele. What are the genotypes of Claudia and Marcus? Claudia: ________________________ Marcus: _____________________ They planned to have four children. What is the probability that: a. all children will be normal b. at least two will be normal