Phylogenetic with branch lengths scaled in genetic distance 0.88 0.88 0.93 0.78 2388-3883 232 2002 9853-2888 0.8 0.82 0.89- 0.9 Mycobacterium tuberculosis Lineage 2 0.99 2001 90-2004 4484 2005 0.63 +385627805 7183883 11 2002 -83331-9811 74333-2690 52505-2010 10737 2002 203 2001 8073_2007 1511-290201 47032810 -049362009-2011 83922889 0153005 98507_2009 8195 200 46839 769803007 Root-to-tip distance Evolutionary distance from root-to-tip versus sampling time 2.8x10 2.2×10 R²=0.00 1990 1995 2000 00 000 80 2005 000 O OD 1000 Boo 2010

Curren'S Math For Meds: Dosages & Sol
11th Edition
ISBN:9781305143531
Author:CURREN
Publisher:CURREN
Chapter16: Adult And Pediatric Dosages Based On Body Surface Area
Section: Chapter Questions
Problem 7.4P
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Phylogenetic with branch lengths scaled in genetic distance
0.88
0.88
0.93
0.78
2388-3883
232 2002
4⁹29930
9823-2883
0.8
0.82
0.89-
Mycobacterium tuberculosis Lineage 2
0.99
2001
90-2004
4484 2005
-0.635
388627805
718356883
11 2002
-83331-9811
74333-2690
$250-2010
10737 2002
203 2001
1511 208201
4701810
2008-2011
6295 29889
8073_2007
0.01 (# substitutions/nucleotide
site)
83922889
015 2005
98507_2009
8195 200
46828000
Root-to-tip distance
Evolutionary distance from root-to-tip versus sampling
time
2.8x10
2.2x10
R²=0.00
1990
1995
2000
00 000
80
2005
000
O
oo
XBOO8
1. In this figure you can see a phylogenetic tree of samples of Mycobacterium
tuberculosis lineage 2 and a corresponding root-to-tip plot. The branch
lengths in the tree are scaled by evolutionary/genetic distance, so not by time.
In the plot on the right, the summed branch lengths going from the root to the
tips of the trees are then plotted against the dates the tips were sampled.
What can we conclude from these figures?
The sampled M. tuberculosis lineage 2 population is measurably evolving
through time during the sampling period.
The root-to-tip distances of the M. tuberculosis lineage 2 samples are
significantly increasing over time.
2010
Based on the used DNA sequences, the M. tuberculosis lineage 2 population is
not measurably evolving through time during the sampling period.
There is no genetic diversity in M. tuberculosis lineage 2 samples taken during
the displayed time period.
Transcribed Image Text:Phylogenetic with branch lengths scaled in genetic distance 0.88 0.88 0.93 0.78 2388-3883 232 2002 4⁹29930 9823-2883 0.8 0.82 0.89- Mycobacterium tuberculosis Lineage 2 0.99 2001 90-2004 4484 2005 -0.635 388627805 718356883 11 2002 -83331-9811 74333-2690 $250-2010 10737 2002 203 2001 1511 208201 4701810 2008-2011 6295 29889 8073_2007 0.01 (# substitutions/nucleotide site) 83922889 015 2005 98507_2009 8195 200 46828000 Root-to-tip distance Evolutionary distance from root-to-tip versus sampling time 2.8x10 2.2x10 R²=0.00 1990 1995 2000 00 000 80 2005 000 O oo XBOO8 1. In this figure you can see a phylogenetic tree of samples of Mycobacterium tuberculosis lineage 2 and a corresponding root-to-tip plot. The branch lengths in the tree are scaled by evolutionary/genetic distance, so not by time. In the plot on the right, the summed branch lengths going from the root to the tips of the trees are then plotted against the dates the tips were sampled. What can we conclude from these figures? The sampled M. tuberculosis lineage 2 population is measurably evolving through time during the sampling period. The root-to-tip distances of the M. tuberculosis lineage 2 samples are significantly increasing over time. 2010 Based on the used DNA sequences, the M. tuberculosis lineage 2 population is not measurably evolving through time during the sampling period. There is no genetic diversity in M. tuberculosis lineage 2 samples taken during the displayed time period.
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