Identify the DNA elements and protein factors, #1- 7, in the figure below that are involved in the initiation and elongation of transcription at a eukaryotic promoter of a gene

Biochemistry
6th Edition
ISBN:9781305577206
Author:Reginald H. Garrett, Charles M. Grisham
Publisher:Reginald H. Garrett, Charles M. Grisham
Chapter29: Transcription And The Regulation Of Gene Expression
Section: Chapter Questions
Problem 8P: Alternative Splicing Possibilities Suppose exon 17 were deleted from the fast skeletal muscle...
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Identify the DNA elements and protein factors, #1-7, in the figure below that are involved in the initiation and
elongation of transcription at a eukaryotic promoter of a gene
TRANSCRIPTION
ON
RNA PROCESSING PefA
A eukaryotic promoter
commonly includes a TATA
box (a nucleotide sequence
TRANSLATION
Ritoom
containing TATA) about 25
nucleotides upstream from
Nontemplate (coding) strand of DNA
7
Pupeptide
1
the transcriptional start point.
Nontemplate (coding or sense) strand
DNA
TATAAAA
ATATILTI
5
2
3
Start point
2 Several transcription
TCCAA
3'
5'
factors, one recognizing
the TATA box, must bind
3' end
to the DNA before RNA
4
polymerase Il can bind in
the correct position and
orientation.
UCCA
3
5'
3'
3 Additional transcription
GGTT
factors (purple) bind to
the DNA along with RNA
5'
Direction of transcription
polymerase II, forming the
transcription initiation
3
complex. RNA polymerase Il
then unwinds the DNA double
helix, and RNA synthesis
begins at the start point on
the temple strand.
3
Transcription initiation complex
Transcribed Image Text:Identify the DNA elements and protein factors, #1-7, in the figure below that are involved in the initiation and elongation of transcription at a eukaryotic promoter of a gene TRANSCRIPTION ON RNA PROCESSING PefA A eukaryotic promoter commonly includes a TATA box (a nucleotide sequence TRANSLATION Ritoom containing TATA) about 25 nucleotides upstream from Nontemplate (coding) strand of DNA 7 Pupeptide 1 the transcriptional start point. Nontemplate (coding or sense) strand DNA TATAAAA ATATILTI 5 2 3 Start point 2 Several transcription TCCAA 3' 5' factors, one recognizing the TATA box, must bind 3' end to the DNA before RNA 4 polymerase Il can bind in the correct position and orientation. UCCA 3 5' 3' 3 Additional transcription GGTT factors (purple) bind to the DNA along with RNA 5' Direction of transcription polymerase II, forming the transcription initiation 3 complex. RNA polymerase Il then unwinds the DNA double helix, and RNA synthesis begins at the start point on the temple strand. 3 Transcription initiation complex
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