Answered: A defective gene on chromosome 15…

Biology Today and Tomorrow without Physiology (MindTap Course List)

5th Edition

ISBN:9781305117396

Author:Cecie Starr, Christine Evers, Lisa Starr

Publisher:Cecie Starr, Christine Evers, Lisa Starr

Chapter9: Patterns Of Inheritance

Section: Chapter Questions

Problem 13SQ

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Question

A defective gene on chromosome 15 causes Tay-Sachs disease. It is a central nervous system neurodegenerative disease that most often affects infants, though older children and adults can have late-onset forms of the disease. The defective gene prevents the body from making a protein called hexosaminidase A. Without, hexosaminidase A, chemicals called gangliosides build up in the nerve cells of the brain, destroying brain cells.

Pedigree information regarding the incidence of Tay-Sachs within a family is depicted above. The row below that indicates the genotypes of individuals II-1, II-2, and III-1 is

Select one:

II-1	II-2	III-1
Aa	Aa	aa

II-1	II-2	III-1
X^AY	X^AX^a	X^AX^a

II-1	II-2	III-1
X^AY	X^AX^A	X^aX^a

II-1	II-2	III-1
AA	aa	Aa

Pedigree of a Family with Tay-Sachs Disease
|
1
3
4
II
1
II
1 2
4

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