Biostatistics Student Journal Club Questions and Answers 10/17/2016 Group #12: Jenna Nixon, Vu Le, Sarah Jacob, Kajri Shah, Andres Brito, Isis Sanders Question #1: What was the null hypothesis of the study and was it accepted or rejected? Answer: The null hypothesis was that there is no association between lower blood sugar and taking the oral glucagon receptor antagonist LY2409021 in healthy and diabetic individuals. The study found that taking the glucagon receptor antagonist does indeed help lower blood sugar in healthy and diabetic individuals with very limited hypoglycemia; therefore, the null hypothesis was rejected Question #2: What ethical guidelines, if any, were used during this research study? Answer: The study used the Declaration …show more content…
Answer: The primary objective was to test if the glucagon receptor antagonist use is safe and if study participants will be able to tolerate the drug. Also, they wanted to test the therapeutics effect of the LY2409021 drug on the study participants and how the participants’ body will affect the drug. Question #4: What measurements were conducted during the study to ensure that the participants were safe? Answer: The subjects in the study were regularly tested on their vital signs, echocardiogram and clinical laboratory tests. Question #5: Was this journal peer reviewed and what was its impact factor? Answer: The journal (Diabetes, Obesity, and Metabolism) had a journal impact factor of 6.198 in 2015, according to InCites. The journal, however, is not peer-reviewed per Ulrich’s Periodicals Directory. Question #6: How were the participants selected for the studies? Answer: The study participants for the studies were selected based on the following criteria: For Type 2 Diabetes Study Participants: Hemoglobin A1C level that 11.1/1, following an oral glucose tolerance test For Healthy Study Participants: BMI 18.5–29.9 kg/m2, Fasting blood glucose level of
3- How would you make it an experimental (rather than correlational) study (it might help to be specific here as well and define the two types of studies in your
A. A three year study done by Boston College found that “tests profoundly shape what
What was the purpose of this study? (i.e., what question(s) did the authors want to answer?)
· Compare the measurements in the study with the standard normal distribution, what does this tell you about the data?
1.What two factors did you investigate in your procedure, and why did you choose to compare these two factors?
How were the results obtained? Can you tell from the article whether this was a case study, an epidemiological study, and intervention study, or a laboratory study? How does that information affect your understanding of what the results have contributed to nutrition science?
1. Describe the context (why it was done, the general interest and what the researchers wanted to find out) of the research and research question (what is the hypothesis). /10
The article that I use as peer reviewed journal is “ Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes”. Type 2 diabetes is considered as the most common disease that affect many people. This is a condition that is associated with a high buildup of sugar in the blood stream. The symptoms are constant hunger, fatigue, lack of energy and frequent urination. At milder levels, the symptoms become severe and lead to the death of an individual. Importantly, it also increases the rate of the cardiovascular disease once an individual has been reported to have such symptoms. The cardiovascular diseases lead to a greater rate of complications in patients with type two diabetes and result in loss of life and also in the United States, it has been rated as one of the leading causes of death. Due to this reason, researchers have focused more on the development of appropriate drugs to improve the treatment of the condition. The article on “semaglutide and cardiovascular outcomes in patients with type 2 diabetes” provides beneficial knowledge to the health-care field.
Were there any unexpected findings? What did the authors conclude? What did the results mean, and what are their implications?
3. Sample Population: Who exactly was used in the study? How many? (Be as specific as possible.)
What were the source of the data collected? For example, who were the participants? What was the sample? What sites for research data collection were used? And/or What documents were studied?
10) Was the sample for this study adequately described? Provide a rationale for your answer
This set of particular tests were carried out at Manchester Metropolitan University in the Interdisciplinary Laboratory. Prior to the tests that were going to be carried out the client in question was asked to carry out a Pre-Test Medical questionnaire to assess the risks involved and to see if the client would be able to participate in the tests. The tests that were performed on the client were height, weight, haemoglobin, cholesterol, FEV1 and FVC.
d. Did data analysis address questions and/or hypotheses of the study? Give a rationale for your
4.The introduction reported significance in 5 areas where null hypothesis were rejected, listed in question 1.