Acetic anhydride

Laboratory 5: Synthesis of Organic Compounds Introduction: In this experiment, aspirin will be synthesized from salicylic acid using acetic anhydride. The sodium salt was initially prescribed for its antipyretic and analgesic effects, but the salt was too irritating to the stomach, so a phenyl ester version was developed as a replacement. The esterified version passed successfully through the acidic stomach without irritation. It was hydrolyzed in the basic environment of the intestines,

the synthesis of acetylsalicylic acid and the synthesis of methyl salicylate. Procedure Part A- Acetylsalicylic Acid (Aspirin) • In a 50 mL Erlenmeyer flask, 1.4 g (0.1 mol) of salicylic acid and 3 mL (3.1 g, 0.03 mol) of acetic anhydride were placed, using the acetic anhydride to wash any salicylic acid from the walls of the flask. Afterwards, 5 drops of phosphoric acid were added, which activated the reaction and subsequent mechanism described in Figure 1.A, and the flask containing the mixture

Paracetamol, the most common medicine nowadays, has been used by people for more than thirty years in order to relieve pain and fever. It acts as a medicine prescribed by doctors. Also, it can be easily purchased as an over-the-counter remedy in retail pharmacies and groceries. Paracetamol can be obtained either in the form of tablets or syrups. Paracetamol injections are introduced in certain cases too. Such drug is suitable and appropriate for all age groups including young children. It can be

The amount of acetic anhydride used was 4.9 mL and 4 drops of concentrated sulfuric acid. The flask was put on a ring stand and put into 55°C water for 10 minutes. After 5 minutes the solution did not dissolve so a spatula was used to break apart the solid pieces to help the

Abstract: This experiment is to demonstrate the preparation of paracetamol and its properties. Reflux and filtration of 4-aminophenol and acetic anhydride formed the crude sample. Further analysis of dry white crystals were used to give quantitative measurements and a percentage yield of 46% was obtained. The overall conclusion is that the acetic anhydride reacted with the –NH2 group. Materials and Methods: 1. We weighed out (on a top-pan balance) 4-aminophenol (about 11.0g) in a weighing

to combine salicylic acid with acetic anhydride with phosphoric acid, H3PO4 to produce aspirin. The formula for salicylic acid is C7H6O. The formula for acetic anhydride is C4H6O3. The formula for phosphoric acid is H3PO4. The phosphoric acid is a catalyst. This reaction is a synthesis reaction. Therefore: C7H6O3+C4H6O3→C9H8O4+C2H4O2 ↑ ↑ ↑ ↑ Salicylic acid acetic anhydride Aspirin Acetic Acid Abstract: Aspirin is an over-the-counter

synthesis the Acetylsalicylic acid which is known as aspirin and calculate the limiting, theoretical, and the melting point. In the second step, the Theoretical yield came out to be salicylic acid seeing it was the smallest out of the phosphoric and acetic anhydride. Experimental melting point-The literature melting point was 138-140 Celsius, when it was prepared in lab, it started melting at 131 and turned into liquid at 138 Celsius. Introduction Acetylsalicylic Acid is an ester of salicylic acid. It is

N-phenylacetamide. The synthesis below, depicts aniline reacting with acetic anhydride yielding acetanilide and acetic acid (amine to amide). Solubility in H20 25 ° C Solubility in water 75 ° Molar mass g/mol Mass (g) Density g/ml # of moles M.P Acetic Anhydride .12 g/mL 102.09 1.08 Aniline .036 g/mL 93.12 .31 1.02 .00333 Acetanilide <.0056 g/mL 135.16 .41 1.22 .00303 114.3 Safety Hazards Acetic Anhydride Irritant (eyes/skin). Toxic by inhalation, flammable Aniline Irritant

determine the purity of the synthesized organic molecule of acetylsalicylic acid using a back-titration method. The objectives of the experiment were achieved by synthesizing the organic molecules of acetylsalicylic acid (using salicylic acid and acetic anhydride), and methyl salicylate (using salicylic acid and methanol). FeCl3 was added to each synthesized product to test for the presence of a hydroxyl group (—OH). FeCl3 reacts with a hydroxyl group to form a brightly coloured magenta

Objective The current experiment introduces the concept of green chemistry on microwave heating to synthesise aspirin, instead of using conventional heating methods. Introduction Aspirin synthesis is a popular experiment undertaken in most organic chemistry teaching laboratories (Montes et al., 2006). Most experimental procedures for aspirin synthesis are undertaken to study the carbonyl nucleophilic substitution reactions either under basic or acidic conditions (Polshettiwar and Varma, 2008; Varma