Acetic anhydride

Abstract Acetic Anhydride and p-Aminophenol were heated in a vial attached to an air condenser to synthesize crude acetaminophen, resulting in 0.097 grams (47.48% yield). The crude acetaminophen was then recrystallized in a solvent of water and methanol over heat resulting in 0.082 grams (39.61% yield) of pure acetaminophen. Melting points of both crude and pure acetaminophen were taken, and found to be 165.9 - 170.9°C and 168.2 - 171.5°C, respectively. The literature melting point of acetaminophen

of Santo Tomas Manila, Philippines ABSTRACT This experiment involved three steps: synthesis of aspirin, isolation and purification, and the estimation of purity of the final product. The synthesis involved the reaction of salicylic acid and acetic anhydride in the presence of a catalyst, phosphoric acid, H3PO4. When the aspirin was prepared, it was isolated and filtered. The percentage yield of the synthesis was calculated to be 78.42%. The experimental melting point range of aspirin was determined

was synthesized from a reaction between salicylic acid and acetic anhydride. Acetic anhydride was added to salicylic acid to create a solution and phosphoric acid was added to catalyze the reaction. After the salicylic acid was fully dissolved in a boiling water bath, water would be added to decompose the remaining acetic anhydride. Through the process of filtration, aspirin crystals were collected and separated from the remaining acetic acid-water solution. Then, the product of the reaction would

Carboxylic acid derivatives namely, acyl halides, acid anhydrides, esters and amides were classified through different reactivity tests. The samples used were acetyl chloride for acyl halide group, acetic anhydride for acid anhydride group, ethyl acetate for ester group,

SYNTHESIS AND CHARACTERISTICS OF ASPIRIN- ACETYLSALCYLIC ACID Summary: The lab experiment was divided into parts and the synthesis of the aspirin occurred during the first week. Using 4.032g of salicylic acid 8.0mL of acetic anhydride on a hot bath the reaction was speeded up by the use of a catalyst phosphoric acid. Once the sample was then left to dry in the drawer for a week using the melting point apparatus we conducted the purity assessment of the dried sample. Introduction: Aspirin (acetylsalicylic

acid, was synthesized from salicylic acid and acetic anhydride. In the reaction the hydroxyl group on the benzene ring in salicylic acid reacted with acetic anhydride to form an ester functional group. This method of forming acetylsalicylic acid is an esterification reaction. Since this esterification reaction is not spontaneous, sulfuric acid was used as a catalyst to initiate the reaction. After the reaction was complete some unreacted acetic anhydride and salicylic acid was still be present in the

purity of aspirin by adding Iron (III) chloride to the product. Hypothesis: I hypothesize that salicylic acid will react with acetic anhydride to produce acetylsalicylic acid (aspirin) and acetic acid (vinegar). Variables: Independent and controlled variables: The amount of sulfuric acid used for catalysis and the amount of salicylic acid and acetic anhydride. Dependent variables: Theoretical and actual yield of

percent yield of the aspirin. The synthesis occurs due to a reaction between salicylic acid and acetic anhydride. Once the aspirin was prepared, it was isolated from the reaction solution and purified. The aspirin is insoluble in cold water, and was isolated by filtering the crystallized reaction solution. Purification was necessary to remove any of the unreacted salicylic acid and acetic anhydride. During the experiment, a total of two beakers were used: one that contained the hot water bath and

acid or aspirin was synthesized by the esterification reaction between salicylic acid and acetic anhydride. This esterification reaction consisted of acetic anhydride with a carboxylic acid functional group and salicylic acid with an alcohol functional group making acetylsalicylic acid, which contains an ester functional group. Sulfuric acid was used as a catalyst to make the products of acetic anhydride and acetic acid. The experimental technique of crystallization was used to purify acetylsalicylic

excess acetic anhydride with the salicylic acid. During its synthesis a small quantity of a strong acid is used as a catalyst. Strong phosphoric acid was used as a catalyst in this experiment. The excess acetic acid was quenched by addition of water. Beer’s law shows the relationship