Molecular Biology of the Cell (Sixth Edition)
Molecular Biology of the Cell (Sixth Edition)
6th Edition
ISBN: 9780815344322
Author: Bruce Alberts, Alexander D. Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter Walter
Publisher: W. W. Norton & Company
Question
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Chapter 24, Problem 7P

A.

Summary Introduction

To explain: The part of the viral protein which gives rise to the peptide that is recognized by the clone of cytotoxic T cells.

Concept introduction: T cells and B cells are lymphocytes of the immune system which helps to elicit an immune response against an invading pathogen. T cells are antigen-presenting cells (APC). There are three types of T cells: Cytotoxic T cells, Helper T cells and memory T cells. There are other minor types of T cells like natural killer T cell, γδ T cells and many more. The main function of cytotoxic T cells represented as TC have T-cell receptors on the surface of their plasma membrane that has the capacity to recognize specific antigens that can be even nuclear proteins of the pathogen.

Summary Introduction

To explain: The reason why all viral peptides do not sensitize the target cells for lysis by the cytotoxic cells.

Concept introduction: T cells and B cells are lymphocytes of the immune system which helps to elicit an immune response against an invading pathogen. T cells are antigen-presenting cells (APC). There are three types of T cells: Cytotoxic T cells, Helper T cells and memory T cells. There are other minor types of T cells like natural killer T cell, γδ T cells and many more. The main function of cytotoxic T cells represented as TC have T-cell receptors on the surface of their plasma membrane that has the capacity to recognize specific antigens that can be even nuclear proteins of the pathogen.

B.

Summary Introduction

To explain: The way in which the experiment worked when MHC molecules come to cell surface with peptides already bound.

Concept introduction: T cells and B cells are lymphocytes of the immune system which helps to elicit an immune response against an invading pathogen. T cells are antigen-presenting cells (APC). There are three types of T cells: Cytotoxic T cells, Helper T cells and memory T cells. There are other minor types of T cells like natural killer T cell, γδ T cells and many more. The main function of cytotoxic T cells represented as TC have T-cell receptors on the surface of their plasma membrane that has the capacity to recognize specific antigens that can be even nuclear proteins of the pathogen.

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