A reasonable mechanism for HMG-CoA synthase reaction should be written. Concept Introduction: Acetyl CoA produced by ß oxidation of fatty acids undergoes further oxidation in the TCA cycle. Some of this acetyl CoA is converted into three metabolites; acetone, acetoacetate and ß hydroxybutyrate. Process of formation of these metabolites is known as ketogenesis. Although ß hydroxybutyrate does not have a ketone functional group , those three groups are known as ketone bodies.

Question

Another biochemical study from another patient reveals a 100X increase in the KM value for the enzyme succinyl-CoA synthetase for this individual (only isozyme expressed). What metabolic and physiological consequences would you predict resulting from this enzymatic change?

Answer 1

Question

Chapter 23, Problem 13P

Interpretation Introduction

Interpretation:

A reasonable mechanism for HMG-CoA synthase reaction should be written.

Concept Introduction:

Acetyl CoA produced by ß oxidation of fatty acids undergoes further oxidation in the TCA cycle. Some of this acetyl CoA is converted into three metabolites; acetone, acetoacetate and ß hydroxybutyrate. Process of formation of these metabolites is known as ketogenesis. Although ß hydroxybutyrate does not have a ketone functional group, those three groups are known as ketone bodies.

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