Biology
5th Edition
ISBN: 9781260487947
Author: BROOKER
Publisher: MCG
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Chapter 15.1, Problem 1CC
Consequences of Mutations
Concept Check: Based on the fiber-like structures seen in part (c) of this figure, what aspect of hemoglobin structure does a glutamic acid at the sixth position in normal β-globin prevent? Speculate as to how the charge of this amino acid may play a role.
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Using the quarternary structure of hemoglobin shown inFigure 9-3(d), explain in structural terms how a mutation in the β subunit protein could be suppressed by amutation in the a subunit gene.
Suggest probable consequences of the following real or possible hemoglobinmutations. [Note: as shown](a) At β146 (HC3) His → Asp(b) At β92 (F8) His → LeuIn each case, indicate whether a single-nucleotide change is sufficient forthe mutation.
. Suggest probable conseauences of the following real or possible hemoglobin
mutations.
(a) At B146 (HC3) His → Asp
(b) At B92 (F8) His Leu
In each case, tell whether a single-nucleotide change is sufficient for the
mutation.
Chapter 15 Solutions
Biology
Ch. 15.1 - Consequences of Mutations Concept Check: Based on...Ch. 15.1 - Prob. 2CCCh. 15.2 - Prob. 1EQCh. 15.2 - Prob. 2EQCh. 15.2 - Prob. 3EQCh. 15.2 - Prob. 1CCCh. 15.3 - DNA Repair Concept Check: Which components of the...Ch. 15.3 - Why is this person so sensitive to sunlight?...Ch. 15.4 - Prob. 1CCCh. 15.4 - Prob. 2CS
Ch. 15.4 - Prob. 2CCCh. 15.4 - Prob. 3CCCh. 15.4 - Prob. 4CCCh. 15 - Prob. 1TYCh. 15 - Prob. 2TYCh. 15 - Prob. 3TYCh. 15 - Prob. 4TYCh. 15 - Prob. 5TYCh. 15 - The Ames test a. provides a way to determine if...Ch. 15 - Xeroderma pigmentosum a. is a genetic disorder...Ch. 15 - Prob. 8TYCh. 15 - Prob. 9TYCh. 15 - Prob. 10TYCh. 15 - Prob. 1CQCh. 15 - Prob. 2CQCh. 15 - Prob. 3CQCh. 15 - Prob. 1COQCh. 15 - Distinguish between spontaneous and induced...
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- . The process of a protein folding from an inactive unfolded structure to the active folded structure can be represented by the following equation: unfolded protein = folded protein The values of AH and AS° for the folding of the protein lysozyme are: AH = -280 kJ/mol AS = -790 J/mol · K (a) Calculate the value of AG for the folding of lysozyme at 25 °C. (b) At what temperature would you expect the unfolding of lysozyme to become favorable?arrow_forwardPlease fill in the following blanks with the options that correctly finishes the sentence. a. At a low O₂ pressure the [Select] hemoglobin is in a [Select] [Select] [Select] 9 [Select] " bond with [Select] heme, and the protein's central channel is [Select] b. The proximal histidine forms a(n) [Select] state is stabilized. In this conformation state, the heme prosthetic groups is each subunit's heme is more likely to be the proximal histidine is [Select ] bond with while the distal histidine forms a(n) [Select] to thearrow_forwardOnce the chains of peptides that make up lysyl-tRNA synthetase protein are synthesized in ribosomes, lysyl-tRNA synthetase needs to have the proper active site in order to perform its function, explain the process of protein folding necessary to have a proper 3-D structure, include effect of thermodynamics and different states in folding, including what happen when there are prolines that form peptide bonds with other amino acids, and any disulfide bridgesarrow_forward
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