You have been analyzing wing development mutants in Drosophila and have collected the genetic/Western data below. Your epistasis analysis (not shown), suggested your current model that DW-2 is upstream of WL-1. What is a plausible mechanism for how DW-2 regulates WL-1? mutant name wingless-1 doublewing-2 Probed with Ant-Wingless MW standards - mutanttype O DW-2 polyubiquitinates WL-1 null ODW-2 inhibits transcription of WL-1 null - phenotype O DW-2 phosphorylates WL-1 and prevents it from entering the nucleus DW-2 cleaves WL-1 proteolytically Model Ac Mode of regulation Wings DW-2 T Wings

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