You are working on a protein with the following sequence in an area of interest.     -Asp-Leu-Leu-Gln-Glu-Glu-Asp-Glu-Ser-Arg   a. The current structure, solved at pH 7.4, of this segment has an alpha helix that is  disrupted a er the Gln. Why might the alpha helix stop at this residue?       b. This protein is involved in Lysosomes in vivo. The secondary structure of this region is  expected to change into a complete alpha helix. Why might this change into a complete  helix? ( Hint: Lysosomes are acidic!)

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3) You are working on a protein with the following sequence in an area of interest.  
  -Asp-Leu-Leu-Gln-Glu-Glu-Asp-Glu-Ser-Arg  
a. The current structure, solved at pH 7.4, of this segment has an alpha helix that is 
disrupted a er the Gln. Why might the alpha helix stop at this residue?   
  
b. This protein is involved in Lysosomes in vivo. The secondary structure of this region is 
expected to change into a complete alpha helix. Why might this change into a complete 
helix? ( Hint: Lysosomes are acidic!)

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