You are working in a lab that discovers a small molecule inhibitor that prevents biotin from being loaded onto Lys residues in the active site of enzymes. What pathways will be impacted by such a drug? Glycolysis Fermentation Pentose phosphate pathway Gluconeogenesis Glycogen breakdown Glycogen synthesis Which enzyme in the pathway you selected would be inhibited by this drug? Your answer Would the above drug inhibit human aldolase? Yes O No Explain why you said "yes" or "no" to the last question about aldolase and if it would be inhibited or not. 2-3 sentences.

You are working in a lab that discovers a small molecule inhibitor that prevents biotin from being loaded onto Lys residues in the active site of enzymes. What pathways will be impacted by such a drug? Glycolysis Fermentation Pentose phosphate pathway Gluconeogenesis Glycogen breakdown Glycogen synthesis Which enzyme in the pathway you selected would be inhibited by this drug? Your answer Would the above drug inhibit human aldolase? Yes O No Explain why you said "yes" or "no" to the last question about aldolase and if it would be inhibited or not. 2-3 sentences.

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

See similar textbooks

Similar questions

In class, I mentioned that fructose is metabolized differently in the liver compared to glucose. Refer to the figure shown below to calculate the number ofATPs you would expect from the metabolism of fructose in the liver. Show your work! Fructokinase Fructose Fructose-1-P АТР ADP Aldolase B Dihydroxy- acetone phosphate Glyceraldehyde АТР Triose kinase Triose phosphate isomerase ADP 4 - Glyceraldehyde-3-P Glycolysis Руruvate Acetyl-CoA Fatty acids and triglycerides
The epinephrine-mediated “amplificationcascade” of Figure 24.14 has six steps, all of which are catalyticwith one exception. This cascade leads to the activation of glycogenphosphorylase. This enzyme acts in turn on glycogen to yieldglucose-1-phosphate (G-1-P).(a) Which step is not catalytic?(b) If each catalytic step had a turnover (molecules of substrateacted on per molecule of enzyme) of 10, how many moleculesof G-1-P would result from one molecule of epinephrine?(c) What is the biochemical advantage of such a cascade?(d) How is the amplification cascade of this questionreversed?
Which statement is false for transition-state analog enzyme inhibitors? They fit the active site better than the substrate. Although they cannot perfectly mimic a transition state, they are important to the design of new pharmaceutical agents. Phosphoglycolohydroxamate inhibits the glycolytic enzyme aldolase nearly 10,000 times better than dihydroxyacetone phosphate. Due to noncovalent interactions with the active site, this type of inhibitor is reversible.
Skeletal muscle cannot synthesize fatty acids, yet it producesthe enzyme acetyl-CoA carboxylase. Explain the role of thisenzyme
During hyp[erglycemia or diabetes - what two regulatory enzymes are active? Why are they active?
One metabolic scenario that leads to insulin resistance is the elevation of the conccentration of free fatty acids in skeletal muscle cells. Would you expect increased activity of diacylglycerol acyltransferas (DGAT) to reduce or exacerbate the resistance? Explain.
After the training of marathon, lactic acid is accumulated in the athlete's thigh muscle. Compare the physiological functions and Vmax of glycogen phosphorylase in actively working skeletal muscle and that in liver After vigorous exercise, the athlete faints due to low blood glucose level. A liver biopsy test shows excess amount of glycogen is present in the liver. Suggest with explanation, which type of enzyme is defective in this case.
“Glycolysis and Gluconeogenesis are effectively two sides of the same coin”. With theaid of a diagram/s, explain what this statement means by describing the reactions ofeach pathway and discussing their regulation.
Which enzyme activity of the glycogen debranching enzyme is operating during the release of glucose units linked to glycogen branchpoints via a1,6 glycosidic linkage? O phosphorylase activity O phosphatase activity O transferase activity O glucosidase activity
What is the effect of a defective a(1→ 4) phosphatase in Pompe's disease (GSD II)? O Accumulation of abnormal, unbranched glycogen, leading to heart or liver failure and short fife expectancy O Glycogen accumulation in heart, leading to heart failure, muscle weakness, short life expectancy O Absence of UDP-glucose conversion to glycogen, leading to lack of muscle glycogen, exercise intolerance Glycogen accumulation due to lack of glucose-6-phosphate conversion to glucose, leading to liver enlargement, hypoglycemia, short life expectancy O Lack of complete degradation of glycogen to glucose. leading to mild hypoglycemia, enlarged liver and muscle weakness Submit Request Answer
Which class of enzymes catalyzes the following reactions? CH2- CH2- CH2 H2- C- CH2 AST CH2-C CH2 CH-NH + C=O + C=0 + CH-NH ČO0 Čo0 ČO0 ČO0" Aspartate Oxoglutarate Oxaloacetate Glutamate Select one: a. Oxidoreductase O b. Isomerase O c. Ligase d. Transferase
Why is it essential that the mechanisms that activate glycogen synthesis also deactivate glycogen phosphorylase?