Question 1 (a,b,C) *Give and explain the titrationCurve of alanine.(a) - Why is the Curve showing twoparts?(b)- What is significant about theisot isoelectric point?(C)- How is the isoelectric point relatedto the pka values of the two ionizablegroups of alanine?TTCL 10 SEDISPLAY GREATNESS

pH = 1/Log [H+] If [H+] concentration in a solution is high, pH will be low and the solution is…

Answered: *Give and explain the titration Curve…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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Given the titration curve of the hypothetical polyprotic acid X at 0.100 M concentration (pKa1=4.0, pKa2=8.0, pKa3=12.0) titrated with 0.600 M NaOH, identify the pH at point C, H, E, and M.
Q1. Consider the structure of Glutamic acid (pK, values 2.2, 4.3 and 9.7). но HO. H2N H (a) Assign (R) or (S) configuration to the chiral center. (b) Draw the Zwitterionic form of glutamic acid. (c) Calculate the isoelectric point for glutamic acid. (d) At which pH range glutamic acid solution has a net – 1 charge? (e) What is the pH of a glutamic acid solution in which the a-amine group is 70% deprotonated? (show calculation!)
What is the net average charge on the predominant form of lysine at pH values of (a) 2.0, (b) 5.0 and (c) 7.0? CLUE: draw the structure of lysine and show its different charged forms; then consider in which pH domains the pKa values for deprotonation/protonation occur.
Acetone, CH3–(C=0) –CH3, and urea, NH2–(C=0)–NH2, have similar chemical structures. (a) Compare the possible intermolecular forces for acetone with those for urea. (b) Compare the intermolecular forces between phycocyanin and acetone with those between phycocyanin and water. Briefly explain how acetone disrupts the folding in phycocyanin. (c) Compare the intermolecular forces between phycocyanin and urea with those between phycocyanin and water. Briefly explain how urea disrupts the folding in phycocyanin. (d) Compare your experimental observation on the disruption of phycocyanin folding in the presence of acetone with that in the presence of urea. Briefly explain whether your comparison is consistent with the properties of acetone and urea.
Give structures for the following, (a) cis-9-Dodecenoic acid (b) 18:1CA11 (c) A saturated fatty acid that should melt below 30 °C
Give structures for the following, based on the data as shown.(a) cis-9-Dodecenoic acid(b) 18 : 1cΔ11(c) A saturated fatty acid that should melt below 30 °C
Calculate the net charge on the following tripeptides at pH 5.0: (a) Leu-His-Asp [0] (b) Ala-Ile-Val [0] (c) Met-Lys-Arg [+2] (d) Which tripeptide will be retained the shortest on a cation-exchange chromatographic column in a pH 5.0 buffer? Why?
The skeletal structures of the two amino acids, glycine and lysine, are given below along with the values of the relevant acid dissociation constants (pKa). NH,* PK, - 10.79 - HạN*CH2CO,¯ S pK¸=2.35 (CH2)4 - H3N*CHCO,- pK,=9,78 lysine (Lys) glycine (Gly) pK, = 9.18 pK, - 2.16 For an aqueous solution of glycine alone, calculate the value of pH at which the ratio of the concentration of neutral glycine zwitterions to the concentration of protonated cation is 102. On your under each of the following conditions. In the blank, provide the total charge of the dipeptide. (Example: If the charge is two plus write the answer simply as 2, if the charge is negative two write the answer as -2). draw the skeletal structure of the dipeptide, Lys-Gly, when it is solvated in an aque us solution i. pH= 1 ii. pH= 12
e) What would be the predominant ionization states of this amino acid at physiological pH (7.4) and at this pH, what would the ratio of these two states be (show the calculation)?
Calculate the charge and draw the structure of the predominant ion for: (i) Lysine at pH 7.0 (R=-CH2CH;CH;CH¿NH2) (ii) Glutamic acid at pH 7.0 (R=-CH2CH;COOH) (iii) Serine at pH 1.0 (R=-CH2OH)
The amino acid arginine ionizes according to the following scheme: NH₂ I C=N I ΝΗ Part A pl = Submit H (CH₂)3 H-N-C-COOH II HH 1 [ΠΙ ΑΣΦ H H Calculate the isoelectric point of arginine. Express your answer using three significant figures. Request Answer pk-2.17 -H* +H* wwwww NH₂ C=N ΝΗ H (CH₂)3 1 ? H H-N-C-COO- | | H H 11 H pk-8.99 -H* +H* NH₂ I C=N I ΝΗ T (CH₂)3 H H H₂N-C-COO- I H pk - 12.5 -H* +H* NH₂ C=N=H NH I (CH₂)3 H₂N-C-COO- I H IV
Calculate the solubility of Ag,CO3 (in mol/L) at 25 °C in a 0.02 M Na2CO3 solution. Hint: Ag,CO3(s) → 2Ag*(aq) + co3?(ag) Ksp (Ag,CO3) = 8.1 x 10 12 NażCO3(aq) → 2Na*(aq) + CO3 (aq)

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*Give and explain the titration Curve of alanine. (a) - Why is the Curve Showing two parts? (b)- What is significant about the Isot isoelectric point? (Ⓒ)- How is the isoelectric point related to the pka values of the two lonizable groups of alanine?