Why do cancer cells treated with vitamin E succinate appear to be more vulnerable to rupture of their lysosomal membranes (and subsequent apoptosis) than normal cells? cancer cells often have an alkaline cytosol, which destabilizes the alkaline lysosomes cancer cells often have an alkaline cytosol, which destabilizes the acidic lysosomes cancer cells often have an acidic cytosol, which destabilizes the alkaline lysosomes D. cancer cells often have an acidic cytosol, which destabilizes the acidic lysosomes all of the above

Why do cancer cells treated with vitamin E succinate appear to be more vulnerable to rupture of their lysosomal membranes (and subsequent apoptosis) than normal cells? cancer cells often have an alkaline cytosol, which destabilizes the alkaline lysosomes cancer cells often have an alkaline cytosol, which destabilizes the acidic lysosomes cancer cells often have an acidic cytosol, which destabilizes the alkaline lysosomes D. cancer cells often have an acidic cytosol, which destabilizes the acidic lysosomes all of the above

Human Physiology: From Cells to Systems (MindTap Course List)

9th Edition

ISBN:9781285866932

Author:Lauralee Sherwood

Publisher:Lauralee Sherwood

Chapter2: Cell Physiology

Section: Chapter Questions

Problem 11RE

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Similar questions

List four ways by which substances cross the cell membrane and explain the role of lysosomes and peroxisomes in digesting material taken into cells by phagocytosis.
Many of the cell’s hydrolytic enzymes are located in the lysosome, where the pH is ∼5. What would you expect to be the optimum pH for these enzymes, and why would this protect the rest of the cell from the destructive power of these enzymes upon the accidental rupture of a lysosome?
Gaucher disease, caused by the inhibited digestion of lipids, results in the accumulation of fatty acids within many organs in the body and leads to their subsequent dysfunction. Which of the following describes the most likely subcellular component and related process responsible for the development of Gaucher disease? A B с D Lysosomes contain insufficient amounts of enzymes necessary for the metabolism of lipids. The Golgi complex produces vesicles with highly permeable membranes that cannot ef- fectively regulate the movement of particles. Mitochondria are not producing a sufficient amount of ATP required for the digestion of lipids. The rough endoplasmic reticulum contains an unusually high number of ribosomes, re- sulting in an overproduction of digestive enzymes.
HC CH reaction with HC CH lysosome CH CH HC CH3 HC CH3 HC CH HC. CH CH3 CH3 ОН OH inside the cell, propranolol sometimes encounters lysosomes, which alter its NH group as shown above (right). reacting with the lysosomes, propranolol becomes trapped inside the cell and can cause psoriasis or other inflammatory side effects. Use IMFS to explain why the altered propranolol gets trapped. T
Is the following statement true or false? Digestive enzymes in the lysosome are inactivated when the lysosome becomes acidic.
The rigidity of the plasma membrane is an essential characteristic that allows for cells to survive and thrive in various environments. What are examples of conditions or molecules that can alter plasma membrane rigidity?
The fibronectin protein has a tripeptide segment with the sequence RGD, which is important in mediating cell-cell interactions. In a healthy environment, the protein is present at pH 7. In many tumors, the extracellular environment is acidified, for example to pH 6. Does the fraction of tripeptides with net neutral charge increase or decrease in tumors relative to healthy tissue? Justify your answer, and quantify this increase or decrease.
Phagocytosis of a bacterial cell by a macrophage, involves extensive remodeling of the actin microfilaments in the cell cortex to produce extensions of the plasma membrane and formation the phagocytic cup. Based on your knowledge of microfilament assembly/disassembly and related cell membrane deformation, explain the underlying processes that would be involved in formation of the phagocytic cup.
Glucose diffuses slowly through artificial phospholipid bilayers. The cells lining the small intestine, however, rapidly move large quantities of glucose from the glucose-rich food into their glucose-poor cytoplasm. Using this information, which transport mechanism is most probably functioning in the intestinal cells? exоcytosis simple diffusion O phagocytosis facilitated diffusion active transport pumps
Secretory vesicles (destined for exocytosis) that fuse with the plasma membrane only in an intermittent manner (often requiring an environmental signal) are properly referred to as: constitutive secretory vesicles (like those that carry lipids, such as phosphatidylcholine) the v-SNARES the endosomes the t-SNARES regulated secretory vesicles (like those that carry hormones, such as insulin)
Which statement is not true of endoplasmic reticulum? There is smooth and rough endoplasmic reticulum It is found in all living cells. Rough ER has ribosomoes bound to it. Proteins are transported and modified within it Proteins cam be targeted for ER transportation
The plasma membrane is an effective barrier to molecular movement across it, yet many substances do enter and leave the cell. Explain the mechanisms through which this is accomplished and comment on the energy requirements of these mechanisms.