Which of the following statements is NOT true about chromatin architecture? A. The histone tails on heterochromatin are deacetylated B. Heterochromatin is heavily methylated C. Euchromatin is more likely to contain genes that are expressed at that time D. Euchromatin is heavily methylated
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Which of the following statements is NOT true about chromatin architecture?
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- Which of the following statements correctly describes the structure of chromatin around the promoter of an active eukaryotic gene? O A. It is in the form of heterochromatin and the nucleosomes are tightly wrapped. O B. It is in the form of euchromatin and the nucleosomes are cleared from the region allowing for an open and accessible configuration OC.A repressor protein is bound to the chromatin blocking RNA polymerase. O D.Both B and C.Which of the following statements most accurately represent chromatin state and transcription? Group of answer choices 1.Histone deacetylases promote closed chromatin and result in repressed transcription 2.Open chromatin is associated with hypoacetylation and has high levels of transcription 3.Histone acetyltransferases result in hypoacetylation and high levels of transcription 4.Hyperacetylation is associated with closed chromatin and low levels of transcriptionWhich of the following is associated with active chromatin? Check all that apply. A. Centromeres B. heterochromatin C. histone acetylation D. Polytene puffs E. metaphase chromasomes F. transcription of machinery
- A cell is homozygous for a LOF mutation in the histone acetyltransferase (HAT) gene. Which of the following is/are true? a. Chromatin in the cell will be more condensed than usual, decreasing expression of genes that should be expressed. b. This will lead to histones with more positive charges on their tails, increasing the interaction between histones and the DNA backbone. c. This will lead to a decrease in DNA methylation and therefore cause an increase in gene expression. d. Chromatin in the cell will be less condensed than usual, increasing expression of genes that should not be expressed.Write the word TRUE if the statement is correct and if false, replace the underlined words with the correct one. 1. Heterochromatin is typically gene-rich and composed of loosely-packed DNA that is transcriptionally active. 2. Molecular switches regulate the expression of genes by directing where and when genes should be turned on or off depending on the cell signal. 3. DNA Methylation and acetylation of histones are inverselycorrelated 4. Specialized cells produce specialized proteins derived from luxury genes which are constitutively expressed. 5. In mammals, methylation patterns that regulate DNA structure and gene expression become evident from the gastrula stage.Genes are not always active in cells. The cell has evolved to edit its chromatin state in accord with the energy needs of the cell and organism. What are these two kinds of chromatin called and how does chromatin modeling work in cells? Name four of the known families of chromatin remodeling complexes enzyme complexes that act directly on DNA to alter nucleosome composition in transcribed regions.
- Give examples of constitutive and facultative heterochromatin in:a. Drosophilab. humansChanges in chromatin packing correlate with changes in gene expression in most cells. Why do you think this is the case?Give at least one example of a chromosomal structureor function affected by the following mechanisms formodulating chromatin structure:a. Posttranslational changes of the normal histonesfound in the nucleosome
- Which of the following is a type of chromatin remodeling? O the changing of amino acid sequence of histones the changing of chromatin binding sites in the genome O the changing of nucleosome position the changing of nucleotide sequences of the genomeIn eukaryotic chromatin, tightly coiled scaffolding proteins would indicate a region where genes are currently expressed at high levels. True or FalseDefine the following terms: a. chromosome b. chromatin