Which of the following mutations will MOST drastically change the polypeptide sequence for which the DNA codes? 1 base pair change 2 base pair changes 3 consecutive insertions 1 insertion
Which of the following mutations will MOST drastically change the polypeptide sequence for which the DNA codes? 1 base pair change 2 base pair changes 3 consecutive insertions 1 insertion
Human Heredity: Principles and Issues (MindTap Course List)
11th Edition
ISBN:9781305251052
Author:Michael Cummings
Publisher:Michael Cummings
Chapter11: Genome Alterations: Mutation And Epigenetics
Section: Chapter Questions
Problem 13QP: A frameshift mutation is caused by a: a. nucleotide substitution b. three-base insertion c....
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Which of the following mutations will MOST drastically change the polypeptide sequence for which the DNA codes?
1 base pair change
2 base pair changes
3 consecutive insertions
1 insertion
Expert Solution
Step 1 MUTATION
MUTATION
A change in the sequence of DNA or mRNA is known as a mutation.
> The ultimate result of mutated DNA is a changed polypeptide chain than was originally made.
Mutations can be of different types:
❅ Substitution Mutation
- occurs when a base pair is substituted by another base pair.
- transition mutation occurs when a pyrimidine or purine base is substituted by a pyrimidine or purine base respectively.
- transversion mutation occurs when a pyrimidine or purine base is substituted by a purine or pyrimidine base respectively.
❅ Frameshift Mutation
- occurs when the reading frame of the polypeptide is changed such that none of the original amino acids are made from the point where the mutation occurs.
- deletion occurs when one or more bases are deleted from the mRNA sequence.
- insertion occurs when one or more bases are inserted into the mRNA sequence.
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