Urine Vol (L/day) GFR (ml/min) [Urine] mg/ml [Plasma] mg/ml Filtered Load (mg/min) Excretion Rate (mg/min) Clearance (ml/min) Na+ 1.5 125 1.65 3.08 K+ 1.5 125 1.95 0.195 Cl- 1.5 125 2.65 3.5 Glu 1.5 125 0 0.9
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Urine Vol (L/day) |
GFR (ml/min) |
[Urine] mg/ml |
[Plasma] mg/ml |
Filtered Load (mg/min) |
Excretion Rate (mg/min) |
Clearance (ml/min) |
|
Na+ |
1.5 |
125 |
1.65 |
3.08 |
|||
K+ |
1.5 |
125 |
1.95 |
0.195 |
|||
Cl- |
1.5 |
125 |
2.65 |
3.5 |
|||
Glu |
1.5 |
125 |
0 |
0.9 |
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Solved in 3 steps
- Renal Calculations Urine Vol Excretion Clearance [Urine] (ml/min) mg/ml [Plasma] mg/ml GFR Filtered (L/day) Load Rate (ml/min) (mg/min) (mg/min) Na+ 1.5 125 1.65 3.08 K+ 1.5 125 1.95 0.195 CI- 1.5 125 2.65 3.5 Glu 1.5 125 0.9 w wwA 60-year-old woman with history of lung cancer is admitted for weakness and lethargy for 4 weeks. Her serum [Na*] is 120 mEq/L. She weighs 60 kg. Her serum osmolality is 250 mOsm/kg H2O with urine osmolality of 616 mOsm/kg H2O. The diagnosis of SIADH is made. What would be her serum [Na], if she receives 1 L of isotonic saline? A. 122 mEq/L B. 116 mEq/L C. 118 mEq/L D. 120 mEq/L E. 124 mEq/LUrine creatinine: 190 mg/dL .Plasma creatinine: 2.5 mg/dL. 24-hour urine collection: 975 mL. C(ml/min)= (U(mg/dL)x V(mL/min) )/(P(mg/dL))
- A 24hr increase of GFR from 90ml/min to 120 ml/min because of a change of filtration fraction from 0.15 to 0.2 with no change of 24 hr water and sodium intake is expected to cause the following: O A. Decrease renal oxygen consumption OB. Decrease body water OC. Decrease renal plasma flow OD. Decrease volume of urineTable 3. Serum creatinine values at admission and after 12h Admission +12h SCR(mg/dL) 1.55 1.42 Using the “MDRD” (Modification of Diet in Renal Disease) equation for estimating glomerularfiltration, provided below, and the data available in the above table, calculate the patient's (a 34 year old white male) estimated glomerularfiltration rate (eGFR) at admission and 12h after admission.MDRD GFR Equation (mL/min/1.73 m2)= 175 × (Scr)-1.154 × (Age)-0.203 × (0.742 if female) × (1.212 if African American)Based on your calculated values, state whether LF’s function is normal or abnormal?Previous research suggests that patients with asthma have an increased risk for chronic kidneydisease, but the mechanisms underlying this increased risk are poorly understood. Propose one potential mechanism by which asthma might impair kidney function, and discuss how this dysfunction may impair thebody’s ability to respond to respiratory alkalosisUrine creatinine: 180 mg/dL . Plasma creatinine: 2.3 mg/dL . Urine output: 1.6 mL/mi Creatinine Clearance (C) = (Urine Creatinine × Urine Flow Rate) / Plasma Creatinine What is C
- 36. A 3-month-old boy is brought to the emergency department because of a 2-day history of lethargy. Physical examination shows no other abnormalities. The results of laboratory studies are shown: Serum Na+ 165 mEq/L (N=139-146) CI- 130 mEq/L (N=95-105) 334 mOsmol/kg H₂O (N=282-295) Osmolality Urine 1.001 Specific gravity Osmolality 117 mOsmol/kg H₂O (N>200) He is admitted to the hospital. His urine output is increased. His serum ADH (vasopressin) concentration is 24 pg/mL (N=1-5); aldosterone and renin concentrations are within the reference ranges. The urine osmolality remains unchanged after administration of 1-deamino-8-arginine vasopressin. An MRI of the brain and pituitary gland shows no abnormalities. Ultrasonography shows normal kidneys. The most likely underlying cause of the findings in this patient is a defect in which of the following? A) Angiotensin-converting enzyme B) Aquaporin C) 11a-Hydroxylase D) Renin E) Vasopressin receptorsIn a normal adult. bladder capacity ranges from: 1.50 to 100 mL 2. 700 to 900 mL 3.200 to 300 mL 4.500 to 600 mlWhich of the following is true of aldosterone? Aldosterone Increases the number of open Na channels on the apical membrane of distal tubule cells OAldosterone decreases Na- reabsorption and K+ secretion Aldosterone binds to a g protein.coupled receptor OAldosterone is secreted by the macula densa ( డరంకగంగంగt fndroesos in10 ౧umetr of Na• / x• ATT2sంs on the ap/cal mcm br ane of distal tubule.cells
- A 3-month-old boy is brought to the emergency department because of a 20day history of lethargy. Physical examination shows no other abnormalities. The results of laboratory studies are shown: serum: Na+ 165 mEa/L (N=139-146) Cl- 130 mEq/L (N=95-105) Osmolality 334 mOsmol/kg H2O (N=282-295) urine: specific gravity 1.001 osmolality 117 mOsmol/kg H2O (N>200) He is admitted to the hospital. His urine output is increased. His serum ADH (vasopressin) concentraion is 24 pg/mL (N=1-5); aldosterone and renin concentrations are within the reference ranges. The urine osmolality remains unchanges after administration of 1-deamino-B-arginine vasopressin. An MRI of the brain and pituitary gland shows no abnormalities. Ultrasonography shows normal kidneys. The most likely underlying cause of the findings in this patient is a defect in which of the following?a. angiotensin-converting enzyme b. aquaporin c. 11a-Hydroxylase d. renin e. vasopressin receptorsIn a normal euvolemic person (normal water balance and normal GFR) with plasma [glucose] of 5 mM the clearance of glucose depends on: A. GFR OB. RPF OC. FF OD. None of the aboveCalculate the patient’s output during your 12-hour shift in oz. 600 cc of urine at 0700 2 oz of emesis at 0830 432 mL of urine at 1200 60 mL of emesis at 1600 3 oz of stool at 1800