Typical pharmacokinetic parameters for drug-A are: P-0.1, fex<0.1 fu-0.9: CL 0.32 L/hr/kg; Half-life 6 hr When an IV-bolus (Dose 450 ma) is administered to a 54 kg patient every 6 hours, the maximum plasma concentration at steady state is ma/L (round to nearest tenth) nswer 1-1
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- A drug follows linear one compartment pharmacokinetics, ke = 0.14 hr¹ and volume of distribution 18 L. • Calculate a suitable i.v. bolus dose to maintain plasma drug concentrations above 6 mg/L for 8 hours. What is the initial plasma concentration? (C) • What is half life of this drug? (t1/2) Please select one: a.C-16.5 mg/L t1/2=5 h b.C=14 mg/L 11/2=2.5 h c.C=17.5 mg/L 11/2=3 h d.C=20.6 mg/L t1/2=5 h e.C-18.4 mg/L t1/2=5 hA 129.8 pound patient was prescribed an oral antidepressant. The medication was prescribed as 50 mg PO Q8 H. This antidepressant has a 10.4 hour elimination half-life, a 0.8 L/kg volume of distribution, a 30.7% oral bioavailability, and a 1.5 hour absorption half-life. What is the average steady state drug concentration of the antidepressant in this patient? NOTE: Please provide your answer in units of µg/L. Do not include units in your answer.The biexponential equation for a two compartment model drug is C1,t = 50.0e-1.64t + 20.0e-0.147t. The drug is administered as a rapid IV bolus at t = 0. After 2.00 hours how many mg/l will the drug concentration in the central compartment be.
- You are requested to recommend a dosage regimen for a patient (5S years old, 80 kg) to achieve plasma levels of 25 mg/L of an antiepileptic agent with an elimination half-life of 11 hrs and an apparent Vd of 0.02 L/kg. The tablets are 75% bioavailable and are available as 10 mg and 40 mg tablets. The ideal dosage regimen for this patient is: 10 mg twice daily 10 mg four times a day 40 mg daily 40 mg twice dailyAnalgesia plan for a cat with urinary obstruction: Buprenorphine (for pain) 4.54kgx0.03mg/kg =0.1362mg÷0.3mg/ml=0.45ml Meloxicam (Anti-inflammatory): 4.54 kg x 0.3 mg/kg = 1.3662 mg ÷ 5 mg/ml = 0.27 ml * Please calculate for 4 days, since the cat will remain in the hospital for 4 days.Calculate how much you need for the following dosages 36 You have haloperidol injection 5 mg in 1 mL; amount required = 6 mg. 37 You have diazepam suspension 2 mg in 5 mL; amount required = 5 mg. 38 You have codeine phosphate syrup 25 mg in 5 mL; amount required = 30 mg. 39 You have co-trimoxazole injection 480 mg in 5 mL; amount required = 2,040 mg. What volume and how many ampoules do you need?
- A 100 ml vial of alteplase, a thrombolytic drug, contains 100 mg of drug equivalent to 58,000,000 international units to be administered via intravenous infusion. Determine the units administered to a patient who weighs 172 lb at a dose of 0.9 mg/kg and the volume of injection to use. 43,100,200 units: 78.60 mL 50,810,000 units: 75.50 mL O45,500,700 units: 73.80 mL 40,808,800 units: 70.40 mLA C D B Log drug dose CENTR O In reference to this figure, compare the 4 drugs as to (1) efficacy and SENTE (2) potency. UNIVERSITY WRITE ANSWER AFTER THIS LINE: (1) Based on efficacy (2) Based on potency ResponseCes) SOLVE THE FOLLOWING PROBLEMS OF DOSE CALCULATION, SHOW THE CALCULATIONS FOR EACH OF THEY: 8. If nembutal is used to anesthetize patients at a dose of 0.09mg/g body weight and the concentration of the solution is 60mg/ml. How many mL are needed to anesthetize a 4 pound patient? 9. Atropine is given in doses of .5mg/kg. How much will a patient who weighs 3.5 lbs receive? 10. To anesthetize a patient, a 10 ml bottle of Ketamine is available at a concentration at 10% If the dose of Ketamine in cats is 15 mg/Kg and the patient weighs 4 pounds. Calculate a) Weight of the patient in Kg. b) mg of Ketamine needed to anesthetize the patient. c) Volume in ml of Ketamine. I