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Methadone elimination has very large patient to patient variability. A slow
1. 2.5 days
2. 6.5 days
3 4.5 days
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- Drug A has an half-live of 6 hours, a volume of distribution of 40 liters, and a bioavailability fraction of 0.4. The administration of a 200 mg oral tablet to a 62 year old patient give an AUC = 17.9 mg/L/hr. Calculate the total body clearance ? Please answer it. I will really upvoteYou are requested to recommend a dosage regimen for a patient (5S years old, 80 kg) to achieve plasma levels of 25 mg/L of an antiepileptic agent with an elimination half-life of 11 hrs and an apparent Vd of 0.02 L/kg. The tablets are 75% bioavailable and are available as 10 mg and 40 mg tablets. The ideal dosage regimen for this patient is: 10 mg twice daily 10 mg four times a day 40 mg daily 40 mg twice dailyA client has been ordered Minipress (prazosin hydrochloride) 2 mg po twice a day (first 2 mg dose to be taken in the morning and the second 2 mg dose to be taken at bedtime). The medication is available as Minipress (prazosin hydrochloride) 1 mg capsules. 1. what is the main conversions factor that you will be using to solve this equation? 2. How many capsules should be administered to this client for the whole day?
- A%252F%252Fbbniagaraccc.sln.suny.edu%252Fwe ignment Saved The drip rate of a dobutamine IV depends on the dose (in mcg/min), the weight of the patient, and the dobutamine solution concentration (in mg/ml). For a concentration of 2 mg/ml, the drip rate (in ml/hour), is described by the following formula: Drip rate = 0.03 [patient body mass (kg) × dose infusion rate (mcg/kg-min)] For a patient weighing 209 pounds and a dose infusion rate of 20 mcg/min for every kilogram of body mass, what is the IV drip rate? ml/hrAccording to the diagram attached the therapeutic range of the drug is considered low, this means that the drug is: 120 MTC 100 80 60 40 МЕС 20 10 12 time in hours Select one: Not very safe It is very safe It is very potent It is not very potent concentrationA patient with a rash gets a combination prescription from his physician to help alleviate the itching and moisturize the skin. The prescription is for 60% ingredient A and 40% of ingredient B for a total of 155 g (in a single tube). The patient has 3 refills on this prescription and wants to pick up the entire amount today: how much in g is that? Hint: 3 refills includes an original prescription so the total amount to be picked up is 4 tubes)
- 100 mg dose of Drug X is administered via IV at 7 hours, blood drug concentration is 5 mcg/mL Half-life of the Drug X is 5 hours A. Find the blood concentration after 6 hours if the dose is 1g (should be between 50.39 and 61.6) B. Minimum effective concentration is 2 mcg/mL. IF the first dose was 100mg of Drug X, how many hours after the dose would reach to 2mcg/mL. (When should the 2nd dose be given). (should be between 12.06 and 14.74)Answer the questions based on the data table. [s] mM 0.333 0.40 0.50 0.666 1.0 2.0 V (M/s) Uninhibited 1.65 x 107 1.86 x 107 2.13 x 107 2.49 x 107 2.99 x 107 3.72 x 107 V (M/s) x 107 Inhibitor A 1.05 x 107 1.21 x 107 1.43 x 107 1.74 x 107 2.22 x 107 3.08 x 107 Determine the Km and Vmax of the enzyme. Determine the type of inhibition imposed by inhibitor A. Determine the type of inhibition imposed by inhibitor B. V (M/s) x 107 Inhibitor B 0.794 x 107 0.893 x 107 1.02 x 107 1.19 x 107 1.43 x 107 1.79 x 107A patient needs to receive 50 mL of Claforan (cefotaxime) IV over 30 minutes with a drop factor of 60 gtt/mL. Calculate how many drops per minute are required so that all 50 mL is infused over 30 minutes.
- Nervousness, heart palpitations and tachycardia are symptoms of toxicity of which of the following drugs? Question 23 Not yet answered Marked out of O Methimazole 1.00 O Levothyroxine P Flag question PTU PropranololYour patient is admitted with cellulitis and is ordered cephalexin 0.5g PO every six hours. The safe dosage parameter is 25mg/kg/day PO in 2 to 4 divided doses (Max: 2 g/day). Your patient weighs 176 pounds. The medication is available in 250mg tablets Is the patient’s daily dose within the safe dose parameters? Show your calculationsThe plasma of half-life of aspirin is t1/2 = 20 minutes; ibuprofen t1/2 = 2 hours. Both agents are dosed q 4 to 6 hours. Compared to ibuprofen, APAP's dosing can be much longer than it's plasma half-life because it is: 1. more toxic, so cannot be taken as often 2. more selective for COX1 than is ibuprofen 3. an irreversible inhibitor