Chapter15: Medications, Diet-drug Interactions, And Herbal Products
Section: Chapter Questions
Problem 3SC
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Question
Naloxone is sometimes added to PO phenanthrene formulations to reduce injection abuse while retaining pain relief when used properly. Naltrexone is not used in this way because naltrexone:
1. is orally bioavailable
2. will reduce conversion of the opioid pro-drug
3. will cross the blood brain barrier.
4. has a longer half-life
5. should only be used for opioid maintenance therapy
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