THE MOLECULAR GENETICS OF SICKLE CELL ANEMIA The following is the base sequence of DNA that codes for first eight amino acids of the ß chain of hemoglobin. The ß chain of hemoglobin contains a total of 147 amino acids so this is a small part of the entire gene. DNA Template Strand: TACCACGTGGACTGAGGACTCCTC 1. What is the minimum number of DNA nucleotides in this whole gene? 2. What is the sequence of bases on the strand of DNA that is complementary to the template strand? 3. What mRNA will be formed from the template strand of DNA?

Human Anatomy & Physiology (11th Edition)
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Author:Elaine N. Marieb, Katja N. Hoehn
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THE MOLECULAR GENETICS OF SICKLE CELL ANEMIA
The following is the base sequence of DNA that codes for first eight amino acids of the B chain of hemoglobin. The B chain of hemoglobin contains a total of 147 amino acids so this is a small part of the entire gene.
DNA Template Strand:
TACCACGTGGACTGAGGACTCCTC
1. What is the minimum number of DNA nucleotides in this whole gene?
2. What is the sequence of bases on the strand of DNA that is complementary to the template strand?
3. What mRNA will be formed from the template strand of DNA?
4. What amino acids will this mRNA code for?
5. If the 20th base in the template strand of the DNA is changed from T to A, rewrite the new template strand below.
6. When the template strand of the DNA is changed, this is referred to as a mutation. What kind of mutation is this?
8.
7. What mRNA will be formed from the mutated template strand of DNA?
What amino acids will this new mRNA from the mutated template strand code for?
9. Are these new amino acids the same as the amino acids formed from the original template strand of the DNA? If not, how are the new amino acids different?
3
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Transcribed Image Text:THE MOLECULAR GENETICS OF SICKLE CELL ANEMIA The following is the base sequence of DNA that codes for first eight amino acids of the B chain of hemoglobin. The B chain of hemoglobin contains a total of 147 amino acids so this is a small part of the entire gene. DNA Template Strand: TACCACGTGGACTGAGGACTCCTC 1. What is the minimum number of DNA nucleotides in this whole gene? 2. What is the sequence of bases on the strand of DNA that is complementary to the template strand? 3. What mRNA will be formed from the template strand of DNA? 4. What amino acids will this mRNA code for? 5. If the 20th base in the template strand of the DNA is changed from T to A, rewrite the new template strand below. 6. When the template strand of the DNA is changed, this is referred to as a mutation. What kind of mutation is this? 8. 7. What mRNA will be formed from the mutated template strand of DNA? What amino acids will this new mRNA from the mutated template strand code for? 9. Are these new amino acids the same as the amino acids formed from the original template strand of the DNA? If not, how are the new amino acids different? 3 E $ R F 5 6 G 8 9 C O P
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