A virus is a small infectious agent that multiplies solely inside an organism's live cells. It doesthis by infiltrating the host cell with its genetic material (RNA) and integrating it with the hostgenome. Explain in detail how organisms remove viral gene expression. How does thistechnique work to keep viruses at bay?

A virus is an infectious entity that replicates sub microscopically inside a live cell. Various…

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Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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Some retroviruses that have a wide host range have been developed for use in treatment of diseases or syndromes. These viruses do not result in a productive infection because they lack critical genes for viral replication, but they do carry DNA sequences that allow them to be packaged into infectious particles. Once in the host cell the viral DNA is released and integrates into the cell's genome. The advantage to this strategy is that the delivery of the DNA is very efficient. What is one possible problem of using a virus that can integrate into the human nuclear genome? Multiple Choice The virus carries genes that will interfere with host cell activities. The viral DNA sequences could still cause a disease. Since the viral DNA sequences no longer contain essential genes for viral replication the host cell may not be able to replicate either. The integration could disrupt an essential gene or genes.
Which of the following is a known characteristic or procesds that can lead to genetic changes in some viruses? When two different viral strains of the same type of virus infect a single individual, reassortment/mixing of segmented genome pieces can occur, resulting in new combinations of segments. Genetic rearrangements of the viral genome occurs as a result of duplicate operons in the viral genome undergoing homologous recombination. Environmental conditions trigger the SOS response in viruses, and leads to generation of errors/mutations in the viral genome. Viral RNA polymerases display proofreading capability in replicating the viral genome of certain viruses.
Which of the following is a known characteristic that can lead to genetic changes in some viruses? Operons in the viral genome can undergo homologous recombination, leading to genetic rearrangements. Reassortment of segmented genomes can occur if a host cell is co-infected with two different viral strains. RNA polymerases used in replication of the viral genome have proofreading capability. Environmental conditions can trigger the SOS response, which triggers mutations in the viral genome.
How do cellular receptors for viruses come about? does host species that a particular virus infects evolve to have the viral receptors? would the above offer any survival and/or reproductive advantages to the host? how likely does the virus mutate so it would recognize (or fit) a particular exiting surface protein on the target cells of the host?
Assume you isolate a single stranded (+) RNA virus. When you examine the proteins in the virus, you find that it does NOT contain replicase enzymes within its capsid. Which of the following is true? This virus must have a gene that encodes replicase. This virus will not be able to enter a host cell. Its genome cannot be translated (the process of translation) by the host cell ribosomes. A DNA copy of the viral genome has to be made before viral genes are expressed. This virus must lack surface antigens.
A patient is asked to participate in a trial using a bacteriophage to treat a Streptococcus infection. The patient is worried that she will end up with a viral infection rather than a Streptococcal infection. How would you address her concerns? – discuss the specificity of viral infections. How do they infect host cells, is that a random process?
Viruses may be latent for a long period of time. For example, HIV may be latent for many years, during which new viruses are not made. What are three different mechanisms of viral latency?
An antimicrobial drug binds to the HIV reverse transcriptase enzyme, preventing it from working. Which of the following is true of this drug? It would inhibit early replication steps of some viruses, but not affect normal eukaryotic cell activity. It would directly interfere with translation of some viral proteins and some eukaryotic proteins. It would block assembly/maturation steps of some viruses, and interfere with translation in eukaryotic cells. It would interfere with release of newly formed viruses from a host cell, but not affect eukaryotic cells. It would interfere with protein synthesis in bacteria, but not affect eukaryotic ribosomes. It would interfere with mRNA transcription in bacteria and viruses, but not affect eukaryotic transcription.
Bacteria exposed to viruses incorporate sections of the virus’s DNA into the CRISPR array sequences in their genome. This mechanism allows bacteria to fight off the viruses, like an immune response: the information in CRISPR spacers served as “coordinates” for recognizing and cutting up invading DNA sequences. Describe what might happen under the conditions described after a bacteriophage infects a bacterial cell and releases its DNA into the bacterial cell. Explain why: 1. The invading phage DNA is recognized by the Cas proteins but not inserted into the CRISPR array region of the bacterial genome: The bacteria will be unable to elicit an immune response and will succumb to the phase infection 2. The cas genes on the bacterial genome contains a missense mutation that increases its cleavage/cut activityThe bacteria will elicit an immune response that will successfully fight the phage infection
A patient is admitted to the hospital with a viral infection and is immediately treated with broad-spectrum antibiotics. How will the course of the infection be affected by this treatment? The infection's length will remain the same because viruses do not have DNA or RNA, and so antibiotics do not affect them. The infection's length will be shorter because antibiotics can prevent viral entry into the cell by binding to host-receptor proteins. The infection's length will remain the same because antibiotics have no effect on eukaryotic cells or viruses. The infection's length will be shorter because antibiotics activate the immune system, and this decreases the severity of the infection.
Why must primary cell cultures be restarted every so often when preparing primary cell cultures to observe morphological changes caused by cells infected by a virus? Why are tumor cells preferred? Why are non-enveloped viruses generally more resistant to disinfectants than are enveloped viruses? A public health physician isolated large number of phages from rivers used as a source of drinking water in western Africa. They physician is very concerned that humans might become ill from drinking this water, although she knows that the phages specifically attack bacteria. Why is she concerned?
Describe Specialized transduction: transfer of specific genetic material by means of a virus carrier.

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sma agent iplies solely side an organism this by infiltrating the host cell with its genetic material (RNA) and integrating it with the host genome. Explain in detail how organisms remove viral gene expression. How does this technique work to keep viruses at bay?