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8.What is a primary function of tumor suppressor genes.
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- 1. Explain BRIEFLY whether each of the following conditions will increase or decrease the chance of cancer: a. a mutation in the promoter region of a tumor suppressor gene that results in that gene being overexpressed (assume that the cell is heterozygous for the mutation) b. a mutation in the promoter region of a protooncogene that results in that gene being overexpressed (assume that the cell is heterozygous for the mutation) c. a homozygous mutation that completely eliminates the coding region of a protooncogene d. a homozygous mutation that completely eliminates the coding region of a tumor suppressor gene e. a heterozygote where one allele is the mutant allele described in (c), the other allele being wild type f. a heterozygote where one allele is the mutant allele described in (d), the other allele being wild type1. True or Flase: Cells must only divide when they receive a signal to divide. 2. BRCA1 is a gene that codes for a tumor suppressor protein. If a person inherits a mutation in BRCA1, it greatly increases his or her risk of developing breast cancer. Are the cancer-causing mutations in the BRCA1 gene more likely to: a) increase expression of the gene b)decrease expression of the gene c)not affect the expression of the gene34. List and describe common manifestations of cancer? a) Local effects of tumors b) Systemic effects of malignant tumors.
- 12.What is field of cancerization? Explain part A and B of this figure. How does it explain field of cancerization?| (A) mutation mutation mutation mutation morphologically normal morphologically abnormal, hyperplastic, dysplastic, or neoplastic (D) tumor 1 tumor 2 (8) 7,8,9 10 wild-type p53 only G-T45. wt p53 NORMAL PATCH FIELD CARCINOMA 17p 3p, 9p, 8p, 189 11g Figure 11.14 The Biology of Cancer (0 Garland Sdener 2014)19. Tumor suppressor genes/Oncogenes: Describe how viruses can lead to cancer formation in animal hosts. In your response, describe the terms tumor suppressor gene, proto-oncogene, and oncogene. Use HPV as an example of how different types of tumors may develop and why it may be advantageous to a virus to interfere with proto- oncogenes or tumor suppressor genes.1. A brief intrwhich introduces ALP as a diagnostic tool in cancer and create a Graphical Abstract to summarise the role of ALP in cancer?
- 1. Compare the consequences of a mutation that occurs in the Ras proto-oncogene and a mutation that occurs in the p53 tumor-suppressor gene.3. The normal function of one tumor-suppressor gene is to prevent cells with damaged chromosomes and DNA from "progressing from G to S," whereas another tumor suppressor gene prevents "passage from G21 to M." When these tumor-suppressor genes fail to work, cancer can result. Explain what the phrases in quotations mean.1. What is the importance of understanding the structures and functions of molecules involved in the ability of cancer cells to grow and spread?
- 46. Explain why mutations in oncogenes are generally dominant while those in tumor suppressor genes are recessive.1. For each of the following genes, categorize them as a tumor suppressor gene or a protooncogene. Please explain each choice. Gene Proto-oncogene or tumor suppressor gene? Explanation Bcl-2 Rb Ras APC p532. The TP53 gene normally functions as a tumor suppressor by preventing abnormal cell growth but is commonly found mutated in cancer cells, resulting in uncontrolled cell growth. You plan to use genetic tools to remove mutated TP53 from plasma cells. Answer the following questions. A) Which genetic tool is most appropriate for this application, gene therapy or gene editing? Explain why.