QUESTION 22 Mutations in p53 and Rb are found in a majority of cancers. What type of mutations are these? Gain-of-function mutation in p53 and loss-of-function mutation in Rb Loss-of-function mutations in both genes Gain-of-function mutations in both genes Loss-of-function mutation in p53 and gain-of-function mutation in Rb

QUESTION 22 Mutations in p53 and Rb are found in a majority of cancers. What type of mutations are these? Gain-of-function mutation in p53 and loss-of-function mutation in Rb Loss-of-function mutations in both genes Gain-of-function mutations in both genes Loss-of-function mutation in p53 and gain-of-function mutation in Rb

Biology 2e

2nd Edition

ISBN:9781947172517

Author:Matthew Douglas, Jung Choi, Mary Ann Clark

Publisher:Matthew Douglas, Jung Choi, Mary Ann Clark

Chapter10: Cell Reproduction

Section: Chapter Questions

Problem 43CTQ: ______ can trigger apoptosis if certain cell-cycle events fail. How does this regulatory outcome...

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Question 41 The mechanism of activation of eukaryotic genes involves addition and removal of phosphate residues from some of the transcription factors. (A) True B) False
QUESTION 25 What is the value of identifying prevalent base changes found in different cancer types? This information can be used to choose the right type of treatment This information can help determine what environmental agent is responsible for the cancer There are so many mutations in cancer, this information is not very informative
Question 7 The extent to which a given gene is transcribed depends upon (A the single transcription factor bound to the transcription start site (B the combination of translational factors bound to its upstream regulatory elements the particular combination of transcription factors bound to its upstream regulatory elements D the particular combination of transcription factors bound to its downstream regulatory elements
QUESTION 7 Most polymorphisms do not result in a phenotypic difference because they are typically O either missense or neutral mutations. O either missense mutations or are in promoter regions. O either silent mutations or are in non-coding regions. O nonsense mutations.
Question 23 All may be RNA polymerase Il promoter constituents EXCEPT: A the core element where general transcription factors (GTFS) bind. B) where silencers bind repressors. response elements or GC box D a TATA box upstream the transcription start site.
Question 38 Enzymes that acetylate the e-amino group of lysine in the histone tails are calledand are involved in initial events in transcriptional activation. A histone methylases B histone methyltransferases c) histone acetyltransferases D histone deacetylases
Question 1: The figure shows key components of gene transcription in a eukaryotic cell. Indicate what component (A to E) in the drawing corresponds to each of the following: Enhancers, Promoter Proximal Elements, Basal/General Transcription factor, Transcriptional Activators, Mediator Enhancers_______ Promoter Proximal Elements_________ Basal/General Transcription factor____________ Transcriptional Activators___________ Mediator______________ From the list above which proteins bind to enhancers/regulatory switches? Question 2. What is the role of TFIIH in eukaryotic transcription? How would a mutant of TFIIH that is deficient in kinase activity affect transcription? Answer:
question 26 What is true for CpG Islands: stretches of a few hundred base pairs of DNA where cytosines are unmethylated are not associated with genes are not found around the promoters are associated with silenced genes
Question 1 options: The specificity pocket of the serine protease chymotrypsin, which interacts with Tyr and Phe-containing peptide sequences, contains a Ser residue. A research group is trying to modify chymotrypsin such that it has a low KM with Trp-containing peptides. Enter the name or abbreviation of an amino acid that the Ser could be mutated to that would likely have the desired effect. (Hint: look at the diagrams of the specificity pockets shown in the course slides, and consider how the Ser would need to change to account for the difference between Tyr/Phe and Trp.)
QUESTION 39 Histone acetylation leads to which of the following events? a. DNA becomes more tightly wound around the histone proteins, decreasing the potential level of transcription of the genes found in that stretch of DNA (i.e., genes are silenced or "muted") b. DNA becomes more relaxed, increasing the potential level of transcription of the genes found in that stretch of DNA (i.e., increased access to genes) Oc. DNA is converted into a series of phospholipids, which can then be incorporated into the membrane of the cell d. RNA polymerase is recruited, allowing for the start of DNA replication e. None of the above O O
Question 9 Both conservative and replicative transposition result in movement of the transposon; however, only conservative transcription Group of answer choices A. Transfers the transposition to the new location without copying it B. Has transposase that cuts at inverted repeats and target sequences C. Produces a second copy of the transposon sequence D. Inserts the transposon sequence into target sequences
Question 8 Which of the following statements is FALSE regarding Enhancers? O Enhancers are sometimes found in introns and at the 3' end of genes. O Enhancers can activate transcription in either orientation (flip or flop). O Enhancers are often located upstream of the core promoter elements. O Enhancers are not present in yeast, nematodes and Drosophila.