Predict the dominant form of the amino acid shown below at pH 10.0. Given: pKa a-carboxyl 2.2, pka a-amino 9.1, pKa side chain 10.5 HN-CH-CH CH₂ H₂ OH

Introduction to General, Organic and Biochemistry
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Author:Frederick A. Bettelheim, William H. Brown, Mary K. Campbell, Shawn O. Farrell, Omar Torres
Publisher:Frederick A. Bettelheim, William H. Brown, Mary K. Campbell, Shawn O. Farrell, Omar Torres
Chapter22: Proteins
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Problem 22.35P: 22-35 Why is histidine considered a basic amino acid when the pKa of its side chain is 6.0?
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Predict the dominant form of the amino acid shown below at pH 10.0.
Given: pka a-carboxyl 2.2, pka a-amino 9.1, pka side chain 10.5
H₂N-CH-C-OH
CH₂
OH
Transcribed Image Text:Predict the dominant form of the amino acid shown below at pH 10.0. Given: pka a-carboxyl 2.2, pka a-amino 9.1, pka side chain 10.5 H₂N-CH-C-OH CH₂ OH
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