Please provide neat and clean handwriting and clear image Insulin does not enter the cell that it affects. Instead, it starts a signal cascade within the cell. The signal culminates with theregulation of insulin-sensitive cytosolic enzymes and the transcription of specific nuclear genes that regulate metabolism.Place the steps of the insulin signaling pathway that regulates gene transcription in the order in which they occur. Not all thesteps will be placed.Insulin binds its receptor.Transcription factors activate.Answer BankINSR autophosphorylates.Sos facilitates GDP release and GTP binding to Ras.Ras activates the first of three protein kinases in a series.Raf phosphorylates MEK, which activates ERK. A protein kinase enters the nucleus.INSR phosphorylates IRS1. PKB inactivates GSK3, thereby activating GS.Grb2 assists the interaction between IRS1 and Sos.PKA activates downstream cytosolic enzymes.INSR phosphorylates GRK.

Cell signaling is the way of communication of cells. It involves cascades of chemical reactions in…

Answered: Insulin does not enter the cell that it…

Human Physiology: From Cells to Systems (MindTap Course List)

9th Edition

ISBN:9781285866932

Author:Lauralee Sherwood

Publisher:Lauralee Sherwood

Chapter4: Principles Of Neural And Hormonal Communication

Section: Chapter Questions

Problem 18RE

See similar textbooks

Similar questions

Which of the following is a consequence of insulin signaling? (select all that apply) Cell growth/division genes upregulated Increased cellular glucose uptake through GLUT4 transporter glycogen degradation Glucose synthesis
Chronic stress or GC exposure can cause insulin resistance. The influence of GC on insulin is complex, but leads to hyperinsulinemia (high circulating insulin levels) and insulin resistance. Insulin resistance is typically caused by a decreased number of insulin receptors on the cell surface. Speculate on a mechanism resulting in a decreased number of insulin receptors.
Glycogen breakdown is stimulated by a signaling cascade that is an excellent example of signal amplification. Amplification in glycogen breakdown is where a small number of signal molecules (hormones) activate a rapid and large release of glucose. Which of the following is the correct sequence for this signaling cascade in skeletal muscle cells? O epinephrine, GPCR, Protein kinase A (PKA), phosphorylase b kinase O insulin, insulin receptor (RTK), protein phosphatase-1 (PP1), glycogen phosphorylase glucagon, GPCR, Protein kinase A (PKA), glycogen synthase O epinephrine, protein phosphatase-1 (PP1), phosphorylase b kinase, glycogen synthase insulin, insulin receptor (RTK), protein phosphatase-1 (PP1), bifunctional enzyme, glycogen synthase
Normally, when blood glucose level increases (e.g. after a meal), the islet cells in the pancreas secrete insulin. When insulin molecules bind to insulin receptors on the surface of a muscle cell, the receptors become activated, initiating a signaling pathway which eventually results in the increase in the number of passive glucose transporter on the muscle cell surface thus increases the uptake of glucose into the cell and decrease blood glucose level. Indicate whether the following conditions/practice will likely lead to diabetes (mark Yes or No). [Select] degeneration of islet cells [Select] [Select] [Select] a mutation in the insulin receptor that increases its kinase activity ✓ exercise a mutation in the insulin receptor that prevents dimerization
What protein is activated in the cytoplasm due to activation of the insulin receptor? protein kinase A glycogen phosphorylase protein phosphatase 1 glycogen synthase kinase insulin-receptor substrate
If you chug water when you’re hungry, you’ll temporarily feel full because of the _________ signaling pathway, but you’ll stay full if you eat a bacon (fat), egg (protein), and cheese sandwich (bread=sugars) because of the __________ signaling pathway. Leptin; insulin Mechanical; chemical Chemical; mechanical Insulin; leptin
People with non-insulin-dependent diabetes mellitus are generally not ketosis prone. This is thought to be a result of: the lack of increase in glucagons in the se individuals the presence of insulin in the individuals their obesity the fact that, their blood glucose levels do not tend to rise significantly Metabolic actions of insulin include all of the following except: increased glycogenesis decreased gluconeogenesis increased basal metabolic rate increased skeletal muscle amino acid up-take all of the above are metabolic actions of insulin
Place the following steps (showing how a steroid hormone changes the activities of its target cells) in order of what happens first, second, third, fourth, and last. Refer to image. The hormone-receptor complex enters the nucleus of the cell and binds to the DNA. The steroid hormone passes through the cell membrane. The hormone attaches to a receptor in the cytoplasm, forming a hormone-receptor complex. A gene in the DNA is activated, and transcription and translation take place. Proteins that alter the cell′s activities, such as enzymes, are made. 2. Place the following steps (showing how a hydrophilic hormone changes the activities of its target cells) in order of what happens first, second, third, and last. Refer to image. The activity of the target cell is changed by the final enzyme in the cascade. The second messenger activates or deactivates certain enzymes in a cascade fashion. A second messenger is activated. Hormone binds to a receptor protein.
Match the molecule involved in insulin signaling with what it does insulin receptor [Choose ] [Choose] physically pushes glucose out of the cell physically brings glucose into the cell binds to insulin and sends signal to cell a protein hormone that signals cells to import glucose signals cells to export glucose a carbohydrate taken into cells as an energy source glucose insulin glucose transporter [ Choose ] 近
Epinephrine binds to a G-protein linked receptor present on the liver cells and activates the G-protein signaling pathway within the cell. This signally cascade finally activates the enzyme glycogen Phosphorylases. The activated glycogen Phosphorylases then produces Glucose -1 Phosphate from the breakdown of glycogen. This glucose is then released into blood stream. If this G-protein receptor for epinephrine is nonfunctional, will there be an increase in the conc. of which of the following molecules - Multiple answers: Multiple answers are accepted for this question Select one or more answers and submit. For keyboard navigation. SHOW MORE a CAMP b. Glucose-1- phosphate Neither CAMP more Glucose -1- phosphate
What kind of protein is the reactor in insulin signaling pathway: a ligand-gated channel, a G protein-linked receptor, or an enzyme- linked receptor? The receptor activates a specific kind of protein, Based on what that protein does, what is it called?
Practice question 1B) Mutations in the signalling pathways depicted above have been associated with an increased incidence of several types of cancer. Individuals with the se cancers may be treated with one of the following chemotherapeutic drugs. Complete the table below about their me chanisms of action. In which cellular Which process is targeted first compartment/structure/organelle by this drug? Drug Drug's mechanism of action does this proce ss occur? (replica tion, mitosis, transcription, translation, or If more than 1 location, be sure to specify ALL relevant locations. none of the above)? A Inhibits microtubule assembly Create inter- or intra-strand crosslinking in DNA preventing strand separation Inhibits synthesis of non-essential amino acids Drug CH3 HN HN PPPO O N. PPPO O OH OH 5-deoxythymydine triphosphate (DTTP) 5-deoxyuridine triphosphate (DUTP)

SEE MORE QUESTIONS

Recommended textbooks for you

Human Physiology: From Cells to Systems (MindTap …

Biology

ISBN:

9781285866932

Author:

Lauralee Sherwood

Publisher:

Cengage Learning