In receptor mediated endocytosis, the receptors (such as the low-density lipoprotein, LDL, receptor) can enter the coated pits even when they don't bind their ligands. Tor F
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- If the RGD tripeptide sequence in fibronevtin wete absent. Which is true? integrims would not bind to fibronectin cadherins on adjacent cells would not be able to interact in a homotypic fashion. fibronectin could not form crosslink with other extracellular matrix proteins. glycosaminoglycans would not be able to assemble onto proteoglycans.What is the significance of the protein-lined pits? O Protein attracts other proteins needed for ATP synthesis within the cell. Protein-lined pits are able to transport one molecule at a time down the concentration gradient within the cell. The polarity of proteins allows other polar molecules to attach and be transported in the cell by transport channels. Receptors within the pits allow ligands to fuse and be transported into the cell by endocytosis.The amino acid sequence Leu-His-Arg-Leu-Asp-Ala-Gln-SerLys-Leu-Ser-Ser is a signal sequence that directs proteinstowards the endoplasmic reticulum, say if it is true or false if it is false justify it.
- REEP family proteins act as wedges to promote bending of the membrane true or falseIn receptor-mediated endocytosis, each of the following could be a fate for the receptors and/or vesicle contents except recycling to the plasma membrane digestion in a lysosome. All are possible fates. release from the vesicle into the peroxisome. transcytosis.Various types of vesicle coats have been implicated in membrane traffic pathways suchas endocytosis, export from the ER to the Golgi, and transport between Golgicisternae. But so far, no coat has been identified for the secretory vesicles that carrymaterial from the Golgi to the plasma membrane. Do you think such a coat is likely toexist? Justify your answer.
- Which of the following are involved in receptor-mediated endocytosis? Choose all that apply. There are 2 correct answers. You will LOSE points (from the total correct) for incorrect answers. This is to discourage guessing. clathrin dynamin COPII ARF COPI phagosomeGlucose diffuses slowly through artificial phospholipid bilayers. The cells lining the small intestine, however, rapidly move large quantities of glucose from the glucose-rich food into their glucose-poor cytoplasm. Using this information, which transport mechanism is most probably functioning in the intestinal cells? exоcytosis simple diffusion O phagocytosis facilitated diffusion active transport pumpsDiscuss the potential benefit of receptor-mediatedendocytosis
- Why is receptor-mediated endocytosis said to be moreselective than phagocytosis or pinocytosis?An individual transport vesicle will fuse with only one type of membrane O is enclosed by a membrane with the same lipid and protein composition as the membrane of the docking membrane is endocytic if its traveling toward the plasma membrane contains only one type of protein in its lumenWhen William H. was helping victims after a devastating earthquake in a region not prepared to swiftly set up adequate temporary shelter, he developed severe diarrhea. He was diagnosed as having cholera, a disease transmitted through unsanitary water supplies contaminated by fecal material from infected indiv iduals. The toxin produced by cholera bacteria causes Cl- channels in the lurninal membranes of the intestinal cells to stay open, thereby increasing the secretion of Cl- from the cells into the intestinal tract lumen. By what mechanisms would Na+ and water be secreted into the lumen in conjunction with Cl- secretion? How does this secretory response account for the severe diarrhea that is characteristic of cholera?