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Consider the structure of the tripeptide (in its fully protonated form) below. H O H I | || + O=C CH₂ C=O T OH H I H₂N-C-C-N-C-C-N-C-C-OH I T I H CH₂ H AA1 O=C HC-CH3 CH3 AA2 CH₂ AA3 1. Give the sequence of the tripeptide using the ONE-LETTER DESIGNATION (UPPERCASE LETTER) with NO spaces and symbols between each letter. 2. How many ionizable groups are there in the tripeptide? Give the numerical value (e.g., 10 not ten). • pH 10: {Choices: -2, -1, 0, +1, +2} 3. Which amino acid residue has one ionizable group left upon forming the tripeptide? {Choices: AA1, AA2, AA3, none, all} 4. Give the net charge of the dominant structure of the tripeptide at the given pH values. The pK, values of the amino acids are given in Table 1. • pH 4: {Choices: -2, -1, 0, +1, +2}

Consider the structure of the tripeptide (in its fully protonated form) below. H O H I | || + O=C CH₂ C=O T OH H I H₂N-C-C-N-C-C-N-C-C-OH I T I H CH₂ H AA1 O=C HC-CH3 CH3 AA2 CH₂ AA3 1. Give the sequence of the tripeptide using the ONE-LETTER DESIGNATION (UPPERCASE LETTER) with NO spaces and symbols between each letter. 2. How many ionizable groups are there in the tripeptide? Give the numerical value (e.g., 10 not ten). • pH 10: {Choices: -2, -1, 0, +1, +2} 3. Which amino acid residue has one ionizable group left upon forming the tripeptide? {Choices: AA1, AA2, AA3, none, all} 4. Give the net charge of the dominant structure of the tripeptide at the given pH values. The pK, values of the amino acids are given in Table 1. • pH 4: {Choices: -2, -1, 0, +1, +2}

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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Consider the structure of the tripeptide (in its fully protonated form) below. H H H + I || H₂N-C-C-N-C-C-N-C-C-OH 1 I | H CH₂ H CH₂ CH₂ T C=O OH AA1 0=0 || HC-CH3 CH3 AA2 AA3 0=C 1. Give the sequence of the tripeptide using the ONE-LETTER DESIGNATION (UPPERCASE LETTER) with NO spaces and symbols between each letter. 2. How many ionizable groups are there in the tripeptide? Give the numerical value (e.g., 10 not ten). • pH 10: {Choices: -2, -1, 0, +1, +2} 3. Which amino acid residue has one ionizable group left upon forming the tripeptide? {Choices: AA1, AA2, AA3, none, all} 4. Give the net charge of the dominant structure of the tripeptide at the given pH values. The pK, values of the amino acids are given in Table 1. • pH 4: {Choices: -2, -1, 0, +1, +2}
Transcribed Image Text:Consider the structure of the tripeptide (in its fully protonated form) below. H H H + I || H₂N-C-C-N-C-C-N-C-C-OH 1 I | H CH₂ H CH₂ CH₂ T C=O OH AA1 0=0 || HC-CH3 CH3 AA2 AA3 0=C 1. Give the sequence of the tripeptide using the ONE-LETTER DESIGNATION (UPPERCASE LETTER) with NO spaces and symbols between each letter. 2. How many ionizable groups are there in the tripeptide? Give the numerical value (e.g., 10 not ten). • pH 10: {Choices: -2, -1, 0, +1, +2} 3. Which amino acid residue has one ionizable group left upon forming the tripeptide? {Choices: AA1, AA2, AA3, none, all} 4. Give the net charge of the dominant structure of the tripeptide at the given pH values. The pK, values of the amino acids are given in Table 1. • pH 4: {Choices: -2, -1, 0, +1, +2}
Amino acid Gly Ala Val Leu lle Pro Phe Tyr Trp Ser Thr Cys Met Asn Gln Asp Glu Lys Arg His Table 1. pk, values of the standard amino acids. pK₂1 (a-carboxyl) 2.34 2.34 2.32 2.36 2.36 1.99 1.83 2.20 2.38 2.21 2.11 1.96 2.28 2.02 2.17 1.88 2.19 2.18 2.17 1.82 pK₂2 (protonated α-amino) 9.60 9.69 9.62 9.60 9.68 10.96 9.13 9.11 9.39 9.15 9.62 10.28 9.21 8.80 9.13 9.60 9.67 8.95 9.04 9.17 pKar (side chain) 10.07 8.18 3.65 4.25 10.53 12.48 6.00
Transcribed Image Text:Amino acid Gly Ala Val Leu lle Pro Phe Tyr Trp Ser Thr Cys Met Asn Gln Asp Glu Lys Arg His Table 1. pk, values of the standard amino acids. pK₂1 (a-carboxyl) 2.34 2.34 2.32 2.36 2.36 1.99 1.83 2.20 2.38 2.21 2.11 1.96 2.28 2.02 2.17 1.88 2.19 2.18 2.17 1.82 pK₂2 (protonated α-amino) 9.60 9.69 9.62 9.60 9.68 10.96 9.13 9.11 9.39 9.15 9.62 10.28 9.21 8.80 9.13 9.60 9.67 8.95 9.04 9.17 pKar (side chain) 10.07 8.18 3.65 4.25 10.53 12.48 6.00
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