Chromosomes core of 8 are composed of 1. forming a structure called a chromatin; DNA; histones; nucleosome nucleosomes; DNA; chromatin: histone which is composed of O DNA; chromatin; nucleosomes: histone wrapped around a
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Oogenesis
The formation of the ovum (mature female gamete) from undifferentiated germ cells is called oogenesis. This process takes place in the ovaries (female gonads). Oogenesis consists of three stages known as the multiplication phase, growth phase, and maturation phase.
Cell Division
Cell division involves the formation of new daughter cells from the parent cells. It is a part of the cell cycle that takes place in both prokaryotic and eukaryotic organisms. Cell division is required for three main reasons:
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- A region of a eukaryotic chromosome that is gene-rich (i.e. contains many genes) would be expected to be in which form chromatin form? Euchromatin O HeterochromatinOne histone modification that is seen consistently inmany species is the addition of an acetyl group to thetwelfth lysine in the H4 protein. If you were a geneticist working on yeast and had a clone of the H4 gene,what could you do to test whether the acetylation atthis specific lysine was necessary for the functioningof chromatin?I. The retinoic acid receptor (RAR) is a transcription factor that is similar to steroid hormone receptors. Thesubstance (ligand) that binds to this receptor is retinoicacid. One of the genes whose transcription is activatedby retinoic acid binding to the receptor is myoD. Thediagram that follows shows a schematic view of theRAR proteins produced by genes into which one oftwo different 12-base double-stranded oligonucleotides had been inserted in the ORF. The insertion site(a–m) associated with each mutant protein is indicatedwith the appropriate letter on the polypeptide map.For constructs encoding proteins a–e, oligonucleotide 1(5′ TTAATTAATTAA 3′ read off either strand) wasinserted into the RAR gene. For constructs encoding proteins f–m, oligonucleotide 2 (5′ CCGGCCGGCCGG 3′)was inserted into the gene.NH2 f g h i j k l m COOHa b c d eThe wild-type RAR protein can both bind DNA and activate transcription weakly in the absence of retinoic acid(RA) and strongly in RA’s presence. Each…
- Give at least one example of a chromosomal structureor function affected by the following mechanisms formodulating chromatin structure:a. Posttranslational changes of the normal histonesfound in the nucleosomeWhich of the following is a type of chromatin remodeling? O the changing of amino acid sequence of histones the changing of chromatin binding sites in the genome O the changing of nucleosome position the changing of nucleotide sequences of the genomeWhich of the following is likely to be transcriptionally expressed? euchromatin and DNA with methyl groups euchromatin DNA with methyl groups DNA with acetylated histones euchromatin and DNA with acetylated histones
- Which of the following statement is true about histone deacetylase? It enables RNA polymerase to bind to the DNA O It is rarely found near the centromere and telomeres of chromosomes O It is frequently associated with euchromatin O It is an enzyme that modifies the lysine residue of histone tailsWhich of the following statements most accurately represent chromatin state and transcription? Group of answer choices 1.Histone deacetylases promote closed chromatin and result in repressed transcription 2.Open chromatin is associated with hypoacetylation and has high levels of transcription 3.Histone acetyltransferases result in hypoacetylation and high levels of transcription 4.Hyperacetylation is associated with closed chromatin and low levels of transcriptionLactose intolerant individuals do not produce the enzyme lactase. Studies show that the gene that encodes lactase is not transcribed. This gene is most likely associated with nucleosomes that are ______________ which can be caused by histone Uncondensed; acetylation Uncondensed; deacetylation Condensed; acetylation Condensed; deacetylation Uncondensed; methylation
- In eukaryotes which of the following combination of chromatin conditions would be most likely to result in the highest levels of expression of gene?Which of the following statements about heterochromatin is FALSE? It contains many repeated sequences, but few actively transcribed genes. It remains condensed through most of the cell cycle. It is found next to the centromeres and on short arms in human chromosomes. It is enriched for transposable elments Histone proteins in heterochromatin are heavily acetylated, reducing their affinity for the DNA backbone.Like Hurler syndrome, Fabry disease involves an abnormal accumulationof substances within lysosomes. However, the lysosomesof individuals with Fabry disease show an abnormal accumulationof lipids. The defective enzyme is α-galactosidase A, which is alysosomal enzyme that functions in lipid metabolism. The enzymaticdefect causes cell damage, especially to the kidneys, heart,and eyes. The gene that encodes α-galactosidase A is found on theX chromosome. Let’s suppose a phenotypically unaffected coupleproduces two sons with Fabry disease and one phenotypicallyunaffected daughter. What is the probability that the daughter willhave an affected son?