Q20 At pH 7, the most predominant interaction between glucuronic acid (structure seen below) and thewhile the interaction with the R-group ofR-group of Arg would be [Select]Tyr would be [Select]OHCOO™ОНOHTyr would be [Select]OHAt pH 7, the most predominant interaction between glucuronic acid (structure seen below) and theR-group of Arg would be ✓ [Select ]while the interaction with the R-group ofCOOOHTyr would be ✓ [Select]OOHOHOHOHelectrostatic interactionhydrophobic interactionhydrogen bondAt pH 7, the most predominant interaction between glucuronic acid (structure seen below) and theR-group of Arg would be [Select]while the interaction with the R-group ofelectrostatic interactionhydrophobic interactionhydrogen bondO.OH>OHOH

Electrostatic interactions are the interactions that might be attractive or repulsive that form…

Answered: At pH 7, the most predominant…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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To calculate the isoelectric point of amino acids having other ionizable functional groups, we must also take into account the pk, of the additional functional group in the side chain. For an acidic amino acid (one with an additional acidic OH group): For a basic amino acid (one with an aditional basic NH group): pK, (a-COOH) + pK, (second COOH) - pKa (a-NH3") + pK, (side chain NH) pl = a. Indicate which pK, values must be used to calculate the pl of each of the following amino acids: [1] glutamic acid; [2] lysine; [3] arginine. b. In general, how does the pl of an acidic amino acid compare to that of a neutral amino acid? c. In general, how does the pl of a basic amino acid compare to the pl of a neutral amino acid?
Given the following peptides below, what would be more soluble at the indicated pH? 1. (Gly)20 or (Glu)20 in pH 7.0 2. (Lys-Ala)3 or (Phe-Met)3 in pH 7.0 3. (Gly)20 or (Glu)20 in pH 6.0|| 4. (Ala-Ser-Gly)s or (Asn-Ser-His)s in pH 6.0 5. (Ala-Asp-Gly)8 or (Asn-Ser-His)8 in pH 3.0
Given the following Peptide: Q6 *H;N-Phe-Asp-Ala-Arg-Gy-His-Arg-Asp-Glu-His-Tyr-CO 6a. What is the peptide's net charge at pH 2.0, pH 6.0, pH 7.4, and pH 10.2? (show work) 6b. What is the approximate isoelectric point of this peptide?
Draw the structure of the pentapeptide Gln-Trp-His-Glu-Tyr that would predominate in acqueous solution at pH=10.3. (Relevant pKa values are: 2.2,4.3,6.0,9.8 and 10.1)
Calculate the overall net charge of the following polypeptide at pH = 2.0 Gly-Pro-Glu-Asp-Leu-His-lle-Gln-Asn-Phe A) +1.76
The following amino acid is dissolved in solution at pH 7.4. HC H' + CH CH₂ H/ H+ HC a. Which amino acid is this? (all lower case) N- H CH CH₂ b. What is the pKa of its ionizable side chain? (Use the value from the textbook.) c. What is the ratio of the uncharged to the charged form at pH 7.4? (write answer as number with one decimal place, ex 2.5 or 0.2 or 50.0 with an implicit "to 1")
Stereochemistry in biological molecules is often denoted by the D- and L- convention, instead of the R- and S- configurations determined by the Cahn-Ingold-Prelog methodology. Naturally occurring α-amino acids are typically in the L-configuration. The Fischer projection of L-alanine is shown. L-alanine H₂N- H3C- HOOC Identify which structures are equivalent to the L-configuration. H COOH H CH3 NH₂ -COOH NH₂ CH3 -H CH3 COOH H -NH₂ H₂N- H CH3 COOH NH₂ H CH3 -COOH
The skeletal structures of the two amino acids, glycine and lysine, are given below along with the values of the relevant acid dissociation constants (pKa). NH,* PK, - 10.79 - HạN*CH2CO,¯ S pK¸=2.35 (CH2)4 - H3N*CHCO,- pK,=9,78 lysine (Lys) glycine (Gly) pK, = 9.18 pK, - 2.16 For an aqueous solution of glycine alone, calculate the value of pH at which the ratio of the concentration of neutral glycine zwitterions to the concentration of protonated cation is 102. On your under each of the following conditions. In the blank, provide the total charge of the dipeptide. (Example: If the charge is two plus write the answer simply as 2, if the charge is negative two write the answer as -2). draw the skeletal structure of the dipeptide, Lys-Gly, when it is solvated in an aque us solution i. pH= 1 ii. pH= 12
write the one letter code for oligopeptide ser-cys-ille-glu-Asn-cys-glu and calculate the total charge on it at pH 4.5 (pKa of Glu side chain is 5.0)
Draw an ionization scheme for each of the amino acids Phenylalanine, Methionine, Tyrosine, Asparagine (from the most acidic form to the most basic form) , and show your computation for the pI/IP of each of the amino acids as well. Draw a complete structural representation for the tetrapeptide Phe-Met-Tyr-Asn (NOTE:use the zwitterion form) Give the IUPAC name for the tetrapeptide formation of F-M-Y-N. List all the possible tetrapeptide formed from one of each amino acids Phe-Met-Tyr-Asn? (NOTE: Use the three letter abbreviation code for the amino acids in answering D)
What is the net average charge on the predominant form of lysine at pH values of (a) 2.0, (b) 5.0 and (c) 7.0? CLUE: draw the structure of lysine and show its different charged forms; then consider in which pH domains the pKa values for deprotonation/protonation occur.
Calculate the charge and draw the structure of the predominant ion for: (i) Lysine at pH 7.0 (R=-CH2CH;CH;CH¿NH2) (ii) Glutamic acid at pH 7.0 (R=-CH2CH;COOH) (iii) Serine at pH 1.0 (R=-CH2OH)

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At pH 7, the most predominant interaction between glucuronic acid (structure seen below) and the R-group of Arg would be [Select] while the interaction with the R-group of Tyr would be [Select] OH COO™ OH OH OH