Acyl transfer (nucleophilic substitution at carbonyl) reactions proceed in two stages via a "tetrahedral intermediate." Draw the tetrahedral intermediateas it is first formed in the following reaction.H3C....NH2HCI/H₂Oreflux• You do not have to consider stereochemistry.• Include all valence lone pairs in your answer.• Do not include counter-ions, e.g., Na+, I, in your answer.• In cases where there is more than one answer, just draw one.+4n [?

Under acidic condition the carbonyl group gets activated by protonation followed by attack by the…

Acyl transfer (nucleophilic substitution at carbonyl) reactions proceed in two stages via a "tetrahedral intermediate." Draw the tetrahedral intermediate as it is first formed in the following reaction. H3C. NH2 HCI/H₂O reflux

Acyl transfer (nucleophilic substitution at carbonyl) reactions proceed in two stages via a "tetrahedral intermediate." Draw the tetrahedral intermediate as it is first formed in the following reaction. H3C. NH2 HCI/H₂O reflux

Organic Chemistry: A Guided Inquiry

2nd Edition

ISBN:9780618974122

Author:Andrei Straumanis

Publisher:Andrei Straumanis

Chapter13: Substitution

Section: Chapter Questions

Problem 4E

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Concept explainers

Aldehydes and Ketones

Aldehydes and ketones are organic compounds that have a carbonyl group, C = O, as their functional group. They both differ in the placement of this carbonyl group in their structures.

Question

Acyl transfer (nucleophilic substitution at carbonyl) reactions proceed in two stages via a "tetrahedral intermediate." Draw the tetrahedral intermediate
as it is first formed in the following reaction.
H3C.
...
NH2
HCI/H₂O
reflux
• You do not have to consider stereochemistry.
• Include all valence lone pairs in your answer.
• Do not include counter-ions, e.g., Na+, I, in your answer.
• In cases where there is more than one answer, just draw one.
+
4
n [
?

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