3. The chemotherapeutic agent, paclitaxel, stabilizes microtubules (proteins that are part of the cytoskeleton) which are shown in green below. Chemotherapeutic agents are meant to kill rapidly dividing cells. A. Why is confocal microscopy an appropriate tool to study the role of paclitaxel on the cytoskeleton and the cell cycle more generally? B. Why would paclitaxel be harmful to a cell? Draw a cell that has been treated with paclitaxel during cell division.

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Author:Elaine N. Marieb, Katja N. Hoehn
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3. The chemotherapeutic agent, paclitaxel, stabilizes microtubules (proteins that are part
of the cytoskeleton) which are shown in green below. Chemotherapeutic agents are meant
to kill rapidly dividing cells.
A. Why is confocal microscopy an appropriate tool to study the role of
paclitaxel on the cytoskeleton and the cell cycle more generally?
B. Why would paclitaxel be harmful to a cell? Draw a cell that has been treated
with paclitaxel during cell division.
C. On the next page is a figure of microtubule length over time during multiple cell
cycles. Analyze the effect of paclitaxel as compared to control. Why does this
data show paclitaxel can be an effective chemotherapeutic agent?
Transcribed Image Text:3. The chemotherapeutic agent, paclitaxel, stabilizes microtubules (proteins that are part of the cytoskeleton) which are shown in green below. Chemotherapeutic agents are meant to kill rapidly dividing cells. A. Why is confocal microscopy an appropriate tool to study the role of paclitaxel on the cytoskeleton and the cell cycle more generally? B. Why would paclitaxel be harmful to a cell? Draw a cell that has been treated with paclitaxel during cell division. C. On the next page is a figure of microtubule length over time during multiple cell cycles. Analyze the effect of paclitaxel as compared to control. Why does this data show paclitaxel can be an effective chemotherapeutic agent?
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