3. Several of the mutant GK enzymes show a normal Vmax but reduced efficiency. What is a reasonable explanation for this observation? a. These mutants have a reduced affinity for the glucose substrate b. These mutants have a reduced value for kcat C. These mutants have a non-functional catalytic triad d. These are all reasonable explanations for this observation

Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
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Patients with a form of early-onset diabetes were found to carry a variety of mutations reducing the function of the
glucokinase (GK) enzyme. These patients are heterozygous for one of the mutations, and thus show only partial
rather than complete loss of GK activity. Answer the following questions about these patients.
How would blood sugar lovolc likoly bo affoctod in CK nautatie
Transcribed Image Text:Patients with a form of early-onset diabetes were found to carry a variety of mutations reducing the function of the glucokinase (GK) enzyme. These patients are heterozygous for one of the mutations, and thus show only partial rather than complete loss of GK activity. Answer the following questions about these patients. How would blood sugar lovolc likoly bo affoctod in CK nautatie
3. Several of the mutant GK enzymes show a normal Vmax but reduced efficiency. What is a reasonable explanation
for this observation?
a. These mutants have a reduced affinity for the glucose substrate
b. These mutants have a reduced value for keat
C. These mutants have a non-functional catalytic triad
d. These are all reasonable explanations for this observation
Transcribed Image Text:3. Several of the mutant GK enzymes show a normal Vmax but reduced efficiency. What is a reasonable explanation for this observation? a. These mutants have a reduced affinity for the glucose substrate b. These mutants have a reduced value for keat C. These mutants have a non-functional catalytic triad d. These are all reasonable explanations for this observation
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