27. In a life-threatening situation when a therapeutic concentration of a drug is neededimmediately, which of the following is the best means for choosing the loading dose?A) Bolus of five times the maintenance doseB) Infusion at five times the normal maintenance rate for 1 half-lifeC) Maintenance dose times body weightD) Maintenance doses with the dose interval equal to the half-lifeE) Steady-state plasma concentration times the volume of distribution

A loading dose is a higher than normal initial dose of a medication that is given to rapidly achieve…

Answered: 27. In a life-threatening situation…

Curren'S Math For Meds: Dosages & Sol

11th Edition

ISBN:9781305143531

Author:CURREN

Publisher:CURREN

Chapter16: Adult And Pediatric Dosages Based On Body Surface Area

Section: Chapter Questions

Problem 5.1P

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1. The desire steady state concentration of a drug is 5mg/l. Clearance of the drug is 30 1/hr and its volume of distribution is 1501. a) What infusion rate will be necessary to reach the target concentration? b) How long will it take to reach steady state? c) What loading dose will be required to instantaneously achieve the steady state?
The nurse caring for a patient who is receiving betal agonist drug therapy needs to be aware that these drugs cause which effect? a )Increased cardiac contractility b) Decreased heart rate c )Bronchoconstriction d)Increased Gl tract motility
54. The volume of distribution of a drug is 350 L. Which of the following is most likely to account for this volume of distribution? OA) Extensive binding to tissue proteins B) Extensive hepatic metabolism C) Inability to cross the blood-brain barrier D) Low lipid solubility E) Rapid renal excretion
While assessing a patient who is to receive muromonabCD3, the nurse knows that which condition would be a contraindication for this drug? a) Acute myalgiab) Fluid overloadc) Polycythemiad )Diabetes mellitus
The physiologic changes that normally occur in older adult patients have which implication for drug * ?response a) Drug elimination is faster. O b) Drug metabolism is quicker. O c) Drug half-life is shortened. d) Protein binding is inefficient. e) All the above O
The desire steady state concentration of a drug is 5mg/l. Clearance of the drug is30 l/hr and its volume of distribution is 150l.a) What infusion rate will be necessary to reach the target concentration?b) How long will it take to reach steady state?c) What loading dose will be required to instantaneously achieve the steady state?
Which of the following is a contraindication to anticoagulant use? A) Recent injury B) Diabetes C) Asthma D) Dizziness Which of the following is an antiplatelet medication? A) Diltiazem B) Labetalol C) Procainamide D) Aspirin A commonly shared action of all antiarrhythmics is that they _____________________. A) Inhibit calcium absorption B) Cause vasoconstriction C) Slow the heart rate D) Prevent bradycardia Which of the following medications is an ACE inhibitor? A) Aspirin B) Labetalol C) Lisinopril D) Simvastatin A Class II antiarrhythmic blocks ____________ channels. A) Potassium B) Beta C) Sodium D) Calcium A potential complication with the administration of a diuretic is ______________________. A) Hypothermia B) Hypernatremia C) Hypokalemia D) Hypoglycemia
Please answer the following questions 1) Vd of a drug will be high when it is distributed in the following tissues except-a) Adipose tissueb) Brain and spinal cordc) Skeletal muscle tissued) Visceral fate) Mesentery tissuef) fats covering kidney and spleen 2) In a 2-comp. open model system the rate of drug disposition between compartents follow-a) zero orderb) 1-orderc) 2-rderd) 3-ordere) mixed orderf) none of the above 3) The likely molecular wt. of a drug for oral absorption is-a) no more than 400b) no more than 350c) no more than 550d) no more than 700e) no more than 650f) no more than 500
A certan antihistamine is often prescribed for allergies. A typical dose for a 100 pound person is 22mg every 6 hours. Complete parts a) and b) below. a) following this dosage, how many 12.3mg chewable tablets would be taken in a week A 100 pound person could take____ tablets in a week. b) this antihistamine also comes in a liquid form with concentration of 12.3 mg/5 ml. Following the prescribed dosage, how much liquid antihistamine should a 100 pound person take a week?
When assessing a patient who is about to receive an albumin infusion, the nurse knows that a contraindication for albumin would bea) acute liver failure.b )heart failure.c )severe burns.d )fluid-volume deficit
49. The bioavailability of drug X after oral administration is 38%. Which of the following best explains this level of systemic bioavailability? A) Adipose distribution B) Hepatic metabolism C) Plasma protein binding D) Pulmonary metabolism E) Renal metabolism
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