1. The desire steady state concentration of a drug is 5mg/l. Clearance of the drug is 30 1/hr and its volume of distribution is 1501. a) What infusion rate will be necessary to reach the target concentration? b) How long will it take to reach steady state? c) What loading dose will be required to instantaneously achieve the steady state?
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- The desire steady state concentration of a drug is 5mg/l. Clearance of the drug is30 l/hr and its volume of distribution is 150l.a) What infusion rate will be necessary to reach the target concentration?b) How long will it take to reach steady state?c) What loading dose will be required to instantaneously achieve the steady state?The desire steady state concentration of a drug is 5mg/l. Clearance of the drug is 30l/hr and its volume of distribution is 150l.a) What infusion rate will be necessary to reach the target concentration?b) How long will it take to reach steady state?c) What loading dose will be required to instantaneously achieve the steady state?27. In a life-threatening situation when a therapeutic concentration of a drug is needed immediately, which of the following is the best means for choosing the loading dose? A) Bolus of five times the maintenance dose B) Infusion at five times the normal maintenance rate for 1 half-life C) Maintenance dose times body weight D) Maintenance doses with the dose interval equal to the half-life E) Steady-state plasma concentration times the volume of distribution
- After oral administration of single 250 mg capsule of an antihypertensive drug to a normal volunteer, the total calculated AUC was 50 mg.hr/L. After intravenous bolus administration of 100 mg, the AUC was 100 hr/L. explain the way plz What is the the absolute bioavailability of the drug from the tablet applied orally? (10. SLAYT) A) 60 % B) 20 % C) 50 % D) 75 % E) 40 %After oral administration of single 100 mg capsule of an antihypertensive drug to a normal volunteer, the total calculated AUC was 20 mg.hr/L. After intravenous bolus administration of 20 mg, the AUC was 10 mg.hr/L. Calculate the absolute bioavailability of the drug from the tablet applied orally. (10. SLAYT) A) 60% B) 20% C) 40% D) 50% E) 75% What sould be the minimum solubility of an active substance (its molecular weight:500) in the dissolution media to be chosen in order to ensure the sink condition in the paddle method by using a 1 liter volume of beaker of a tablet (its dose strength is 100 mg and tablet weight is 200 mg? (4. SLAYT) 1 mg/ml 200 mg/ml 20 mg/ml 5 mg/ ml 10 mg/ mlA certan antihistamine is often prescribed for allergies. A typical dose for a 100 pound person is 22mg every 6 hours. Complete parts a) and b) below. a) following this dosage, how many 12.3mg chewable tablets would be taken in a week A 100 pound person could take____ tablets in a week. b) this antihistamine also comes in a liquid form with concentration of 12.3 mg/5 ml. Following the prescribed dosage, how much liquid antihistamine should a 100 pound person take a week?
- ▪ A patient arrives at the ER complaining of seizures. The patient is taking phenytoin as prescribed which has a therapeutic range of 10-20 ug/mL. You order the SDC and find it is 8 ug/mL at steady state. This is an indication that A) dose needs to be increased. The dose needs to be individualized. ▪ B) The patient is noncompliant.Estimate the new dose and dosing interval for morphine, a high extraction ratio drug in a patient with a Child-Pugh score of 8 if the drug is normally given at a dose of 30 mg every 8 hours. A) 7.5 mg every 8 hours B) 22.5 mg every 8 hours C) 30 mg every 6 hours D) 30 mg every 12 hoursdrug is risperidone Briefly discuss whether the value of the volume of distribution applies to all routes of administration and comment on the distribution of your allocated drug. Calculate how long it takes to a) eliminate 95% of a single dose after absorption, and b) to reach a steady-state blood concentration after repeated dosing at regular half-life intervals. Provide the equations used. Calculate the systemic clearance of your allocated drug. Provide the equation used. Discuss whether this clearance value applies to all routes of administration. Briefly discuss how administering your allocated drug with each of the medicines/foods below would affect the pharmacokinetics and risks of administering your allocated drug: the antibiotic rifampicin, classified as a “potent inducer of CYP3A4” in the AMH; the antibiotic ketoconazole, classified as a “potent inhibitor of CYP3A4” in the AMH. the herbal medicine St John’s wort, is classified as an “inducer of CYP3A4” in the AMH;…
- PO Aav DAV == AaBbCcDdEe AaBbCcDdEe AaBb CcD AaBbCcDdE Normal M H No Spacing Heading 1 Heading 2 Question 5 a) Explain the general principles by which medical images may be obtained through the use of radiopharmaceuticals and a gamma camera. b) Explain the use of radiopharmaceuticals in i) Myocardial perfusion scans ii) Skeletal scintigraphy 20 ¶3) An IV Piggyback of lincomycin containing 5 gms of drug in 175 mL is to be infused over a 1 hour period. The IV set is calibrated to deliver 12 gtt/mL. How many drops per minute should be administered?18. Esmolol 1.2 g in 500 mL D5W has been ordered at a rate of 100 mcg/kg/min for a client weighting 103.2 kg. Determine the following: a) dosage in mcg/min: b) rate in mL/hr c) Is the dosage administered to the client safe?