2. How did the researchers conduct an experiment to search for a "prematurity gene" among African Americans? Explain what happened and what they concluded.
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Premature birth is a problem here in the United States, but especially among the African American communities.
The organization says one in six African American babies are born premature.
Genetic variation in these regions of the genome may be important in the pathogenesis of preterm birth. Many experiment are performed to considered in the design of future genomic studies in prematurity.
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- 1. The first genetic test used a short DNA sequence that was closely linked to the Huntington’s locus. The linkage distance between the DNA sequence used in the test and the actual Huntington’ disease locus was 5%. a. In a large sample of the Venezuelan family (over 2,000 individuals), what percentage of people would inherit the DNA sequence but not the Huntington’s allele (i.e. be a false positive test for Huntington’s)? b. What percentage of that large Venezuelan family would not inherit the DNA sequence but would inherit the Huntington’s allele (i.e., be a false negative test for Huntington’s)?2. Imagine that you are in your late 30s or early 40s and decide that you want a child. You realize that you’re at greater risk of having a child with Down’s Syndrome. What sorts of genetic screening are available today? If you find out that this child has this condition, do you think it’s appropriate to have an abortion? Why or why not? Question: Does elective abortion of fetuses with physical or other developmental disabilities have an effect on the perception of personhood, dignity, and rights in society? Explain.1. The first genetic test used a short DNA sequence that was closely linked to the Huntington’s locus. People taking the test were classified as to whether they had the DNA sequence that was linked to the Huntington’s disease. This method was 95% accurate. This means that 95% of the people who had the Huntington’s-linked DNA sequence actually inherited the Huntington allele. It also meant that 95% of the people who did not have the DNA sequence linked to the Huntington allele did not inherited the wild-type allele (not the Huntington allele).Why might this preliminary test not be as accurate as a gene test for the actual Huntington’s allele? Explain.
- ntml 4 of 9 4. Huntington's disease affects the muscles and nervous system. People who hạve Huntington's'usually get the disease in their 30s. Which of the following is the most accurate statement? A. Huntington's disease could not be due to genetics because genes determine your inherited traits from birth and they do not change in your 30s. B. Huntington's disease could not be due to genetics because everyone's internal organs are the same. C. Huntington's disease could be due to genetics because a slight change in a gene you are born with produces an abnormal protein that eventually leads to a disease. D. Huntington's disease could be due to genetics because most diseases that affect the nervous system are due to genetics. Powered by Linklt!5. Red-Green colour blindness is inherited as an X-linked recessive trait in humans. A woman, who’s mother had red-green colour blindness marries a colour blind man. What are the chances that their child will be: 1. a colour-blind male? 4. a normal male? 2. a colour blind female? 5. a normal female? 5. The couple has a colour blind male child. What are the chances that their next child will be a normal female?4. A. If two parents are both carriers of the autosomal recessive condition cystic fibrosis (CF), what percentage of their offspring would be expected to have CF? B. What is the chance that their first two children will both have CF? C. If they have two children, what is the chance that at least one child will be phenotypically normal?
- 1. What are some of the medical applications of karyotyping? GENETICS syndrome? Down syndrome? 2. What kind of chromosomal aberration is exhibited by individuals with cri-du-chat V. Questions: tet are some of the medical applications of karyotyping? 1. 3. What are other types of chromosomal aberrations? List examples for each type. 4. For a couple, what is the significance of knowing chromosomal aberrations? What environmental factors may increase incidence of chromosomal abnormalities? Name at least three.23. What type of clinical trial did Joseph Goldberger conduct to provide evidence that pellagra was caused by dietary deficiency? O C. Phase II Study with Crossover O B. Phase || Study O D. Phase III Study O A. Phase I Study1. How would you determine whether a disease in humans is simply polygenic (genes from your parents) or has an environmental influence? 2. If identical twins have exactly the same genetic makeup, why are there any differences at all between them? Please write at least 6 sentences for each question.
- 4. A female recently gave birth while in captivity; however, the paternity of the infant is unclear. Scientists tested the DNA from two male cheetahs, along with the female and offspring. The resulting electrophoresis gel is shown. Based on the gel electrophoresis results, what can be concluded about the paternity of the offspring? How do you know? Female = Infant 5- Male 1 Male 24. Why is a gene mutation in a gamete usually more of a concern than a mutation in a somatic cell (i.e. a body cell, other than a sperm or egg)? 5. If a mutation occurred in a gene during gamete formation, resulting in a recessive allele, what would it take for an offspring to express the recessive phenotype? If a mutation occurred in a gene during gamete formation, resulting in a dominant allele, what would it take for an offspring to express the dominant phenotype? 6. In gene therapy an attempt is made to transfer a “normal" gene into the cells of a person who lacks copies of the “normal" gene. Why would scientists and the government be more receptive to somatic gene therapy than to germline gene therapy? 7. 8. Answer the following questions for the two following pedigrees а. In Pedigree A, is the red highlighted trait dominant or recessive? Why? b. What is the genotype of individual C? а. In Pedigree B, is the red highlighted trait dominant or recessive? Why? d. What is the genotype…4. Marfan syndrome is a genetic trait caused by in a dominant allele. The trait causes a weakening of the aorta that can be fatal. A teenager whose mother has the syndrome (but whose maternal grandfather was not affected), and whose father was unaffected, is concerend that she may have the trait. a. What is the phenotype of each of her parents? Genotype? b. What is the chance that the teenager has Marfan syndrome?