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1. What is the distinction between SARS-COV2 and Covid-19?

1. What is the distinction between SARS-COV2 and Covid-19?

Principles Of Pharmacology Med Assist
Principles Of Pharmacology Med Assist
6th Edition
ISBN:9781337512442
Author:RICE
Publisher:RICE
Chapter16: Antifungal, Antiviral, And Immunizing Agents
Section: Chapter Questions
Problem 24RQ
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Names: The world is in a state of pandemic crisis due to the emergence of a new pathogen – SARS CoV2. Conduct outside reading in peer-reviewed journals or national sites such as CDC and integrate this information with material from class. 1. What is the distinction between SARS-COV2 and Covid-19? 2. Compare the molecular nature and size of the SARS-COV2 and HIV genomes and the contents and structure of their virions. 3. What interaction does the HIV virus use to enter cells versus the SARS CoV-2 virus? 4. How can a monoclonal antibody (Regeneron) be used therapeutically? What patient's may benefit from it? 5. What drug designed to treat Ebola is now in clinical trials for Covid-19? How does it work? 6. Explain three different types of ELISA tests. Describe how you could use one of them to detect SARS. 7. Why would ELISA or PCR be a better diagnostic test for Covid-19? 8. What are the limitations in using ELISA and PCR for Covid-19 diagnosis? 9. You are working on a research project involving the SARS-COV2 virus. The spike protein of this corona virus interacts with the ACE-2 receptor protein expressed on human cells. Your lab has developed a competitive inhibitor molecule that is designed to block this interaction and prevent infection. Explain how you would test this drug at the molecular level. Remember, all of the sequence information for expression cloning is present via bioinformatics tools. You do not need to incorporate actual sequence information into your answer. Literature reports that a new mutation in the SARS spike protein may have emerged in Europe through viral evolution. Assuming that this new mutation makes the virus more infective (better able to enter the cell). What can be said about the protein-protein binding dynamics and how might your experimental results differ between original SARS and mutated SARS in your proposed research?
Transcribed Image Text:Names: The world is in a state of pandemic crisis due to the emergence of a new pathogen – SARS CoV2. Conduct outside reading in peer-reviewed journals or national sites such as CDC and integrate this information with material from class. 1. What is the distinction between SARS-COV2 and Covid-19? 2. Compare the molecular nature and size of the SARS-COV2 and HIV genomes and the contents and structure of their virions. 3. What interaction does the HIV virus use to enter cells versus the SARS CoV-2 virus? 4. How can a monoclonal antibody (Regeneron) be used therapeutically? What patient's may benefit from it? 5. What drug designed to treat Ebola is now in clinical trials for Covid-19? How does it work? 6. Explain three different types of ELISA tests. Describe how you could use one of them to detect SARS. 7. Why would ELISA or PCR be a better diagnostic test for Covid-19? 8. What are the limitations in using ELISA and PCR for Covid-19 diagnosis? 9. You are working on a research project involving the SARS-COV2 virus. The spike protein of this corona virus interacts with the ACE-2 receptor protein expressed on human cells. Your lab has developed a competitive inhibitor molecule that is designed to block this interaction and prevent infection. Explain how you would test this drug at the molecular level. Remember, all of the sequence information for expression cloning is present via bioinformatics tools. You do not need to incorporate actual sequence information into your answer. Literature reports that a new mutation in the SARS spike protein may have emerged in Europe through viral evolution. Assuming that this new mutation makes the virus more infective (better able to enter the cell). What can be said about the protein-protein binding dynamics and how might your experimental results differ between original SARS and mutated SARS in your proposed research?
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