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. A clinical test sometimes used to diagnose folate deficiency or B12 deficiency is a histidine tolerance test, where one injects a large dose of histidine into the bloodstream and then carries out a series of bio- chemical determinations. What histidine metabolite would you expect to accumulate in a folate- or B12-deficient patient, and why? In bacteria much of the putrescine is synthesized, not from ornithine but from arginine, which decarboxylates to yield agmatine. Formulate a plausible pathway from arginine to putrescine, using this intermediate. NH, || HạN-C-NH- CH2-CH2- CH2- CH2– NH3 Agmatine

. A clinical test sometimes used to diagnose folate deficiency or B12 deficiency is a histidine tolerance test, where one injects a large dose of histidine into the bloodstream and then carries out a series of bio- chemical determinations. What histidine metabolite would you expect to accumulate in a folate- or B12-deficient patient, and why? In bacteria much of the putrescine is synthesized, not from ornithine but from arginine, which decarboxylates to yield agmatine. Formulate a plausible pathway from arginine to putrescine, using this intermediate. NH, || HạN-C-NH- CH2-CH2- CH2- CH2– NH3 Agmatine

Introduction to General, Organic and Biochemistry
Introduction to General, Organic and Biochemistry
11th Edition
ISBN:9781285869759
Author:Frederick A. Bettelheim, William H. Brown, Mary K. Campbell, Shawn O. Farrell, Omar Torres
Publisher:Frederick A. Bettelheim, William H. Brown, Mary K. Campbell, Shawn O. Farrell, Omar Torres
Chapter21: Lipids
Section: Chapter Questions
Problem 21.56P
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. A clinical test sometimes used to diagnose folate deficiency or B12 deficiency is a histidine tolerance test, where one injects a large dose of histidine into the bloodstream and then carries out a series of bio- chemical determinations. What histidine metabolite would you expect to accumulate in a folate- or B12-deficient patient, and why? In bacteria much of the putrescine is synthesized, not from ornithine but from arginine, which decarboxylates to yield agmatine. Formulate a plausible pathway from arginine to putrescine, using this intermediate. NH, || HạN-C-NH- CH2-CH2- CH2- CH2– NH3 Agmatine
Transcribed Image Text:. A clinical test sometimes used to diagnose folate deficiency or B12 deficiency is a histidine tolerance test, where one injects a large dose of histidine into the bloodstream and then carries out a series of bio- chemical determinations. What histidine metabolite would you expect to accumulate in a folate- or B12-deficient patient, and why? In bacteria much of the putrescine is synthesized, not from ornithine but from arginine, which decarboxylates to yield agmatine. Formulate a plausible pathway from arginine to putrescine, using this intermediate. NH, || HạN-C-NH- CH2-CH2- CH2- CH2– NH3 Agmatine
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