Relate these advantages to explain why radiopharmaceuticals are often used in the treatment of i) prostate cancer (brachytherapy) ii) thyroid cancer (iodine-131 treatment)
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- Answer the following questions:1. If excipients do not have pharmacodynamic activity, how do excipients affect the performance of the drug product?2. What is meant by the rate-limiting step in drug bioavailability from a solid oral drug product?3. What is the usual rate-limiting step for a poorly soluble and highly permeable drug (BCS 2)?4. How could the manufacturing process affect drug product performance?5. Drug absorption involves at least three distinct steps: dissolution, permeation, and disposition during transit in GI (an additional step of drug disposition in the body is involved as well for bioavailability). How are these processes validated in vitro when the in vivo requirement for drug bioavailability is waived?6. What is meant by “sink” conditions?7. What physical or chemical properties of a drug substance are important in designing a drug for (a) oral administration or (b) parenteral administration?8. For a lipid-soluble drug that has very poor aqueous solubility, what…Please give the following information about biopharmaceutical technology. Definition of biopharmaceutical technology (3) future uses of biopharmaceutical technology (3) challenges in biopharmaceutical technology (5) examples of biopharmaceutical technologyFor each of the following drugs, indicate whether the physiological effects of the drug were known before or after the target was identified. a. Penicillin b. Sildenafil (Viagra) c. Rofecoxib (Vioxx) d. Atorvastatin (Lipitor) e. Aspirin f. Indinavir (Crixivan)
- with the antibiotic Triamcinolone answer the questions about its use in animals: 1. CLASSIFY IT STEROID / NON-STEROIDAL 2. MENTION IF IT IS ANALGESIC/ ANTIPYRETIC/ ANTI-INFLAMMATORY. 3. WHAT IS THE MECHANISM OF ACTION? 4. SPECIES IN WHICH IT CAN BE USED (animals) 5. RECOMMENDED TIME OF USE 6. CONTRAINDICATIONS OF ITS USE (WHEN IT SHOULD NOT BE ADMINISTERED IN ANIMALS) 7. SIDE EFFECTS 8. ROUTE OF ADMINISTRATION TO BE USED 9. DOSE (DEPENDING ON THE SPECIES (animal) IN WHICH IT IS ADMINISTERED)In a 55 year old female breast cancer patient whose tumor cells are estrogen sensitive, which of the following chemotherapeutic agents is most likely to control the breast tumor growth but predispose the patient to endometrial cancer? Group of answer choices Tamoxifen Raloxifene Fulvestrant BexaroteneBiDil® is indicated for the treatment of heart failure as an adjunct to standard therapy in self-identified black patients to improve survival, to prolong time to hospitalization for heart failure, and to improve patient-reported functional status. Question 1: What are the generic drugs used to create BiDil®? Discuss the indications for both generics and controversy regarding the use of these 2 generic drugs to create BiDil®?
- While teaching a patient who is about to receive cyclophosphamide (Cytoxan) chemotherapy, the nurse will instruct the patient to watch for potential adverse effects, such as a )cholinergic diarrhea.b )hemorrhagic cystitis.c )peripheral neuropathy.d) ototoxicityWhat is more preferred for drug therapy, conventional or modified release dosage forms? Please provide informations that would support the claim.1) In an experiment, the smaller the sample size, the more credible the results of the study. A) True B)False 2) If you designed an experiment to test the ability of a drug to increase hair growth in men, what would the dosage of the medication given to each man be called? A) Independent variable B) Standardized variable C)Dependent variable D)Control group
- There are 2 main ways of treating tumours - external irradiation by radiotherapy and internal radiopharmaceuticals. Using the points shown below, explain the advantages and disadvantages of using radiopharmaceuticals as opposed to external irradiation. • Area of treatment required • Position of tumour • lonising range • Precautions needed after treatmentWhich of the following adverse drug reactions precludes a patient from being re-challenged with that drug in the future? a. Clostridium difficile superinfection from Moxifloxacin b. All of them c Stevens-Johnson syndrome from sulfamethoxazole +Trimethoprim d. Itching/rash from Penicillin e. Gastrointestinal upset from ClarithromycinAs a pharmacist, propose some improvement that can be implemented to further improve the formulation stability. Answer the following case study using your own words.
