To examine: Whether the statement “The chemical carcinogen dimethybenz[a]anthracene (DMBA) must be an extraordinarily specific mutagen since 90% of the skin tumors it causes have an A-to-T alteration at exactly the same site in the mutant Ras gene” is true or false.
Concept introduction: Mutagens are agents which cause mutation in the gene which results in truncated protein. Ras is an oncogene, which is normally a part of MAP kinase pathway involved in cell cycle. Ras controls cell growth and survival. Skin tumors or melanoma is the abnormal proliferation of epithelial cells of the skin. 7, 12-Dimethylbenz[a]anthracene (DMBA) is a powerful mutagen and immunosuppressor.
Answer to Problem 1P
Correct answer: The statement is false.
Explanation of Solution
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Molecular Biology of the Cell (Sixth Edition)
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