Interpretation:
A series of equations for the synthesis of
Concept introduction:
Grignard and organolithium reagents are nucleophilic. They react with carbonyl groups and form a new carbon-carbon bond.
In the first step, an alkoxymagnesium halide is formed. It is converted to the desired alcohol by reaction with aqueous acid.
If the carbonyl compound is ketone, the product formed is a tertiary alcohol.
Grignard reagents are prepared by the reaction of an
In this reaction, the solvent must be anhydrous. Hence diethyl ether is used.
Hydration of
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Organic Chemistry - Standalone book
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- Organic ChemistryChemistryISBN:9781305580350Author:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. FootePublisher:Cengage Learning