Biochemistry
9th Edition
ISBN: 9781319114671
Author: Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher: W. H. Freeman
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Please intuitively explain what the compartment/s model for drug distribution is.
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- First, we will build a model for the total amount of drugs in the gut. At time \(t = 0\), \(10mg\) of the drug is present in the gut. From the gut, it passes slowly into the blood. The passage of the drug to the blood has first-order kinetics; that is, every hour \(42\%\) of the drug remaining in the gut is passed from the gut into the blood. No more pills are taken, so no extra drug is added to the gut. Let \(a_t\) be the sequence representing the amount of Adderall XR in the patient’s gut \(t\) hours after the pill was taken. Write down a recursion relation for \(a_t\). Find an explicit formula for \(a_t\). Calculate the time at which the amount of drug remaining in the gut drops to \(1\%\) of its starting value; that is, find \(t\) for which \[a_t = 0.01a_0\] Find \(\lim_{t\to\infty}a_t\), what does it represent? Now let’s build a model for the amount of drug in the patient’s blood. Define another sequence \(b_t\) that represents the amount of Adderall XR in the patient’s…arrow_forwardThere are many clinical applications, and the Electronic Drug Store is one of them. So how does it work?arrow_forwardDescribe three situations where you would use an excipient in your drug formulation and how you expect the excipient to help in the very of the active pharmaceutical ingredient.arrow_forward
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