a) 1) The following reaction will not work as written. How can the scientist change this reaction to form the desired product as the major product? (CH3)2Cu-Li+, then H3O+ OH a Use H3CMgBr rather than (CH3)2Cu-Li+ as the first step of the reaction b. Add 2 equivalents of (CH3)2Cu-Li+ C. Use ethanol in the second step rather than hydronium ion d. Protect the ketone before adding (CH3)2Cu-Li+ 2) What is the major product of the following reaction? 0 1. NaOCH3 ? 2. H3O+ OCH3 alls o ge авто d) of a) 1) The following reaction will not work as written. How can the scientist change this reaction to form the desired product as the major product? (CH3)2Cu-Li+, then H3O+ OH a Use H3CMgBr rather than (CH3)2Cu-Li+ as the first step of the reaction b. Add 2 equivalents of (CH3)2Cu-Li+ C. Use ethanol in the second step rather than hydronium ion d. Protect the ketone before adding (CH3)2Cu-Li+ 2) What is the major product of the following reaction? 0 1. NaOCH3 ? 2. H3O+ OCH3 alls o ge авто d) of

r. Please don't provide handwriting solution.

4. Provide the mechanism for this reaction: H3C O cat H* (CH,CH,)NH -Z N CH3

Draw a structural formula for the major organic product of the reaction shown below. ● ● ● ● Br MAX. + [(CH3)3C]2CuLi Consider E/Z stereochemistry of alkenes. Do not show stereochemistry in other cases. You do not have to explicitly draw H atoms. Do not include organocopper or inorganic ion by-products in your answer. #[ ] در ? ChemDoodle Ⓡ

6) Fix the reaction: The following reactions will not work as shown. Explain why the reaction will not work and create a reaction that will work. (Change only reagents. Leave starting material and product CH, H,C CH, Br. hv H,O/H,0 CH HO HO но 1) NANH, 2)CH,Br H3C = HC= CH3 HBr H3C. Br CH3 он CH2 1)MСРВА X, 2) HCI CI

1f) What will be the product of the following reaction? -Br + (HO)₂B- Pd(OAc)2 Degassed H₂O/Acetone

Please fill in the blanks!! Which set of reagents (given below) would produce the products given in the following reaction? A Br₂, hv F NBS K heat B Br₂, DCM G H₂, Pd Br ? с HBr, DCM H LDA L Grubb's D HBr, H₂O I KMnO4 M CH₂l₂, Zn E HBr, H₂O₂ 1. Li, 2. Cul Br

III. Predict the major product(s) or fill in the reagent(s) for the following reactions. If there is no reaction write NR. Show the correct stereochemistry when needed!! HBr (2 equiv.) 1) MCPBA 2) MEONA, MEOH 1) NANH 2) EtBr 3) HSO4, HO 5

Need help on both questions!

I need help with these problems, please advise.