3) How do the a and ẞ anomer of a sugar differ? a anorve a. By the configuration of the acetal carbon in the ring form b. c. By whether a ketone or aldehyde is present in the straight chained form By the presence/absence of a 2' OH d. By whether the OH on the last chiral center is pointed right or left in the Fischer projection of the straight chained form 4) A salt bridge can occur as part of the apply) a. Primary structure b. Secondary structure Tertiary structure d. . Quaternary structure of a protein (select all that 5) True or false: A protein that has been denatured via exposure to acidic conditions is guaranteed to return to its original structure once it has been placed into a neutral environment. a. True b False 6) Why is solid phase peptide synthesis involving a peptide synthesizer generally preferred over solution phase (select all that apply) It leads to less waste b. It is less dangerous It is more reliable It is easier to obtain a pure product 7) What kind of molecules are linked via a glycosidic linkage? a. Amino acids b. Fatty acids C. Monosaccharides d. Nucleotides 8) How are D- and L-amino acids related? a. They are structural isomers b. They are diastereomers c. C. They are conformers d. They are enantiomers 91 of 3) How do the a and ẞ anomer of a sugar differ? a anorve a. By the configuration of the acetal carbon in the ring form b. c. By whether a ketone or aldehyde is present in the straight chained form By the presence/absence of a 2' OH d. By whether the OH on the last chiral center is pointed right or left in the Fischer projection of the straight chained form 4) A salt bridge can occur as part of the apply) a. Primary structure b. Secondary structure Tertiary structure d. . Quaternary structure of a protein (select all that 5) True or false: A protein that has been denatured via exposure to acidic conditions is guaranteed to return to its original structure once it has been placed into a neutral environment. a. True b False 6) Why is solid phase peptide synthesis involving a peptide synthesizer generally preferred over solution phase (select all that apply) It leads to less waste b. It is less dangerous It is more reliable It is easier to obtain a pure product 7) What kind of molecules are linked via a glycosidic linkage? a. Amino acids b. Fatty acids C. Monosaccharides d. Nucleotides 8) How are D- and L-amino acids related? a. They are structural isomers b. They are diastereomers c. C. They are conformers d. They are enantiomers 91 of

In the following monosaccharide hemiacetal, identify the anomeric carbon atom. Identify the appropriate atom by selecting an atom and assigning it a map number of 1. To do this, rigl mark to enable the Map field before entering a value. H: 122 EXP" CONT. 0 0 H но OH S Br OH [1] ÓH P. -

A. What are F and E? (circle the correct answer):   a. Enantiomers b. Diastereoisomers c. Epimers d. Constitutional isomer   B. Indicate which ones are pentoses in the figure     C. Indicate which one is(are) ketose(s) in the figure

4- Salicylamides are inhibitors for an enzyme called scytalone dehydratase. SAR shows that there are three important hydrogen bonding interactions. Explain whether you think quinazolines could act as a bioisostere for salicylamides. HBA OH O 00 N NHR Quinazolines Salicylamides Ph HBA 5- Structure IX (X = NH) is an inhibitor of a metalloenzyme called thermolysin and forms interactions as shown. Explain why the analogue (X = O) has reduced binding affinity by a factor of 1000 and why the analogue (X = SH) has roughly the same binding affinity. Structure IX H HBD Ala-113 R